Intracardiac low-grade sarcoma following treatment for ewing sarcoma

Michael V. Ortiz; Heather Magnan; Emily K. Slotkin; Srikanth R. Ambati; Alexander J. Chou; Leonard H. Wexler; Paul A. Meyers; Michael F. Walsh; Todd Heaton; Leonard N. Girardi; Suzanne L. Wolden; Anita P. Price; Jennifer A. Kennedy; Ahmet Zehir; Meera Hameed; Michael F. Berger; Alex Kentsis; Neerav Shukla

doi:10.1097/MPH.0000000000000754

Intracardiac low-grade sarcoma following treatment for ewing sarcoma

Michael V. Ortiz, Heather Magnan, Emily K. Slotkin, Srikanth R. Ambati, Alexander J. Chou, Leonard H. Wexler, Paul A. Meyers, Michael F. Walsh, Todd Heaton, Leonard N. Girardi, Suzanne L. Wolden, Anita P. Price, Jennifer A. Kennedy, Ahmet Zehir, Meera Hameed, Michael F. Berger, Alex Kentsis, Neerav Shukla

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

Original language	English (US)
Pages (from-to)	e443-e445
Journal	Journal of Pediatric Hematology/Oncology
Volume	39
Issue number	8
DOIs	https://doi.org/10.1097/MPH.0000000000000754
State	Published - 2017
Externally published	Yes

Keywords

Ewing sarcoma
cardiac sarcoma
cell-free DNA
genomics
low-grade sarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/MPH.0000000000000754

Cite this

Ortiz, M. V., Magnan, H., Slotkin, E. K., Ambati, S. R., Chou, A. J., Wexler, L. H., Meyers, P. A., Walsh, M. F., Heaton, T., Girardi, L. N., Wolden, S. L., Price, A. P., Kennedy, J. A., Zehir, A., Hameed, M., Berger, M. F., Kentsis, A., & Shukla, N. (2017). Intracardiac low-grade sarcoma following treatment for ewing sarcoma. Journal of Pediatric Hematology/Oncology, 39(8), e443-e445. https://doi.org/10.1097/MPH.0000000000000754

Ortiz, MV, Magnan, H, Slotkin, EK, Ambati, SR, Chou, AJ, Wexler, LH, Meyers, PA, Walsh, MF, Heaton, T, Girardi, LN, Wolden, SL, Price, AP, Kennedy, JA, Zehir, A, Hameed, M, Berger, MF, Kentsis, A & Shukla, N 2017, 'Intracardiac low-grade sarcoma following treatment for ewing sarcoma', Journal of Pediatric Hematology/Oncology, vol. 39, no. 8, pp. e443-e445. https://doi.org/10.1097/MPH.0000000000000754

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title = "Intracardiac low-grade sarcoma following treatment for ewing sarcoma",

abstract = "A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.",

keywords = "Ewing sarcoma, cardiac sarcoma, cell-free DNA, genomics, low-grade sarcoma",

author = "Ortiz, {Michael V.} and Heather Magnan and Slotkin, {Emily K.} and Ambati, {Srikanth R.} and Chou, {Alexander J.} and Wexler, {Leonard H.} and Meyers, {Paul A.} and Walsh, {Michael F.} and Todd Heaton and Girardi, {Leonard N.} and Wolden, {Suzanne L.} and Price, {Anita P.} and Kennedy, {Jennifer A.} and Ahmet Zehir and Meera Hameed and Berger, {Michael F.} and Alex Kentsis and Neerav Shukla",

note = "Publisher Copyright: {\textcopyright} 2017 Wolters Kluwer Health, Inc.",

year = "2017",

doi = "10.1097/MPH.0000000000000754",

language = "English (US)",

volume = "39",

pages = "e443--e445",

journal = "Journal of Pediatric Hematology/Oncology",

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T1 - Intracardiac low-grade sarcoma following treatment for ewing sarcoma

AU - Ortiz, Michael V.

AU - Magnan, Heather

AU - Slotkin, Emily K.

AU - Ambati, Srikanth R.

AU - Chou, Alexander J.

AU - Wexler, Leonard H.

AU - Meyers, Paul A.

AU - Walsh, Michael F.

AU - Heaton, Todd

AU - Girardi, Leonard N.

AU - Wolden, Suzanne L.

AU - Price, Anita P.

AU - Kennedy, Jennifer A.

AU - Zehir, Ahmet

AU - Hameed, Meera

AU - Berger, Michael F.

AU - Kentsis, Alex

AU - Shukla, Neerav

PY - 2017

Y1 - 2017

N2 - A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

AB - A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

KW - Ewing sarcoma

KW - cardiac sarcoma

KW - cell-free DNA

KW - genomics

KW - low-grade sarcoma

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JF - Journal of Pediatric Hematology/Oncology

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Intracardiac low-grade sarcoma following treatment for ewing sarcoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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