Intracardiac low-grade sarcoma following treatment for ewing sarcoma

Michael V. Ortiz, Heather Magnan, Emily K. Slotkin, Srikanth R. Ambati, Alexander J. Chou, Leonard H. Wexler, Paul A. Meyers, Michael F. Walsh, Todd Heaton, Leonard N. Girardi, Suzanne L. Wolden, Anita P. Price, Jennifer A. Kennedy, Ahmet Zehir, Meera Hameed, Michael F. Berger, Alex Kentsis, Neerav Shukla

Research output: Contribution to journalArticle

Abstract

A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

Original languageEnglish (US)
Pages (from-to)e443-e445
JournalJournal of Pediatric Hematology/Oncology
Volume39
Issue number8
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Ewing sarcoma
  • cardiac sarcoma
  • cell-free DNA
  • genomics
  • low-grade sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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  • Cite this

    Ortiz, M. V., Magnan, H., Slotkin, E. K., Ambati, S. R., Chou, A. J., Wexler, L. H., Meyers, P. A., Walsh, M. F., Heaton, T., Girardi, L. N., Wolden, S. L., Price, A. P., Kennedy, J. A., Zehir, A., Hameed, M., Berger, M. F., Kentsis, A., & Shukla, N. (2017). Intracardiac low-grade sarcoma following treatment for ewing sarcoma. Journal of Pediatric Hematology/Oncology, 39(8), e443-e445. https://doi.org/10.1097/MPH.0000000000000754