Interventions to Slow Aging in Humans: Are We Ready?

Valter D. Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M. Brown-Borg, Calogero Caruso, Tyler J. Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K. Ingram, Thomas E. Johnson, Brian K. Kennedy, Cynthia Kenyon, Samuel Klein, John J. Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G. Mirisola, James R. MitchellGiuseppe Passarino, Karl L. Rudolph, John M. Sedivy, Gerald S. Shadel, David A. Sinclair, Stephen R. Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra, Luigi Fontana

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR-S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.

Original languageEnglish (US)
JournalAging Cell
DOIs
StateAccepted/In press - 2015

Fingerprint

Consensus
Pharmaceutical Preparations
Sirtuins
Education
AMP-Activated Protein Kinases
Aptitude
Insulin-Like Growth Factor I
Italy
Growth Hormone
Rodentia
Fasting
Diet
Genes
Proteins

Keywords

  • Aging
  • Anti-aging
  • Centenarians
  • Dietary restriction
  • Lifespan studies
  • Longevity gene
  • Longevity regulation

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H. M., Caruso, C., ... Fontana, L. (Accepted/In press). Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. https://doi.org/10.1111/acel.12338

Interventions to Slow Aging in Humans : Are We Ready? / Longo, Valter D.; Antebi, Adam; Bartke, Andrzej; Barzilai, Nir; Brown-Borg, Holly M.; Caruso, Calogero; Curiel, Tyler J.; de Cabo, Rafael; Franceschi, Claudio; Gems, David; Ingram, Donald K.; Johnson, Thomas E.; Kennedy, Brian K.; Kenyon, Cynthia; Klein, Samuel; Kopchick, John J.; Lepperdinger, Guenter; Madeo, Frank; Mirisola, Mario G.; Mitchell, James R.; Passarino, Giuseppe; Rudolph, Karl L.; Sedivy, John M.; Shadel, Gerald S.; Sinclair, David A.; Spindler, Stephen R.; Suh, Yousin; Vijg, Jan; Vinciguerra, Manlio; Fontana, Luigi.

In: Aging Cell, 2015.

Research output: Contribution to journalArticle

Longo, VD, Antebi, A, Bartke, A, Barzilai, N, Brown-Borg, HM, Caruso, C, Curiel, TJ, de Cabo, R, Franceschi, C, Gems, D, Ingram, DK, Johnson, TE, Kennedy, BK, Kenyon, C, Klein, S, Kopchick, JJ, Lepperdinger, G, Madeo, F, Mirisola, MG, Mitchell, JR, Passarino, G, Rudolph, KL, Sedivy, JM, Shadel, GS, Sinclair, DA, Spindler, SR, Suh, Y, Vijg, J, Vinciguerra, M & Fontana, L 2015, 'Interventions to Slow Aging in Humans: Are We Ready?', Aging Cell. https://doi.org/10.1111/acel.12338
Longo, Valter D. ; Antebi, Adam ; Bartke, Andrzej ; Barzilai, Nir ; Brown-Borg, Holly M. ; Caruso, Calogero ; Curiel, Tyler J. ; de Cabo, Rafael ; Franceschi, Claudio ; Gems, David ; Ingram, Donald K. ; Johnson, Thomas E. ; Kennedy, Brian K. ; Kenyon, Cynthia ; Klein, Samuel ; Kopchick, John J. ; Lepperdinger, Guenter ; Madeo, Frank ; Mirisola, Mario G. ; Mitchell, James R. ; Passarino, Giuseppe ; Rudolph, Karl L. ; Sedivy, John M. ; Shadel, Gerald S. ; Sinclair, David A. ; Spindler, Stephen R. ; Suh, Yousin ; Vijg, Jan ; Vinciguerra, Manlio ; Fontana, Luigi. / Interventions to Slow Aging in Humans : Are We Ready?. In: Aging Cell. 2015.
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AU - Longo, Valter D.

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AU - Brown-Borg, Holly M.

AU - Caruso, Calogero

AU - Curiel, Tyler J.

AU - de Cabo, Rafael

AU - Franceschi, Claudio

AU - Gems, David

AU - Ingram, Donald K.

AU - Johnson, Thomas E.

AU - Kennedy, Brian K.

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AU - Klein, Samuel

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AU - Lepperdinger, Guenter

AU - Madeo, Frank

AU - Mirisola, Mario G.

AU - Mitchell, James R.

AU - Passarino, Giuseppe

AU - Rudolph, Karl L.

AU - Sedivy, John M.

AU - Shadel, Gerald S.

AU - Sinclair, David A.

AU - Spindler, Stephen R.

AU - Suh, Yousin

AU - Vijg, Jan

AU - Vinciguerra, Manlio

AU - Fontana, Luigi

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