Internal mammary lymph nodal response to neoadjuvant chemotherapy on imaging and breast cancer prognosis

Richard Adam, Tim Q. Duong, Laura Hodges, Jinyu Lu, Takouhie Maldjian

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is an important prognostic indicator in breast cancer. Internal mammary lymph node involvement is not currently included in pCR determination, as sampling at the time of surgery is not routinely performed. Methods: Pre and post neoadjuvant chemotherapy MRI or PET/CT imaging response of the internal mammary lymph node chain was utilized as a surrogate to pCR and imaging data was correlated with patient outcomes. Results: Internal mammary lymph node response to NAC was associated with disease free survival over the course of this study, regardless of whether axillary nodal pCR was achieved. Conclusion: Internal mammary lymph nodal response to NAC is an important prognostic indicator. Potential use of internal mammary lymph node resolution as an imaging data input for AI models that predict pCR post-NAC may improve accuracy and other metrics in pCR prediction.

Original languageEnglish (US)
Article number104900
JournalAnnals of Medicine and Surgery
Volume84
DOIs
StatePublished - Dec 2022
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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