Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

Shaun R. Patel; Todd M. Herrington; Sameer A. Sheth; Matthew Mian; Sarah K. Bick; Jimmy C. Yang; Alice W. Flaherty; Michael J. Frank; Alik S. Widge; Darin Dougherty; Emad N. Eskandar

doi:10.7554/eLife.36460

Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

Shaun R. Patel, Todd M. Herrington, Sameer A. Sheth, Matthew Mian, Sarah K. Bick, Jimmy C. Yang, Alice W. Flaherty, Michael J. Frank, Alik S. Widge, Darin Dougherty, Emad N. Eskandar

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

Original language	English (US)
Article number	e36460
Journal	eLife
Volume	7
DOIs	https://doi.org/10.7554/eLife.36460
State	Published - Sep 2018
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.7554/eLife.36460

Cite this

@article{577826e434e3405ab36c814fe3aea611,

title = "Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects",

abstract = "The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.",

author = "Patel, {Shaun R.} and Herrington, {Todd M.} and Sheth, {Sameer A.} and Matthew Mian and Bick, {Sarah K.} and Yang, {Jimmy C.} and Flaherty, {Alice W.} and Frank, {Michael J.} and Widge, {Alik S.} and Darin Dougherty and Eskandar, {Emad N.}",

note = "Publisher Copyright: {\textcopyright} Patel et al.",

year = "2018",

month = sep,

doi = "10.7554/eLife.36460",

language = "English (US)",

volume = "7",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

AU - Patel, Shaun R.

AU - Herrington, Todd M.

AU - Sheth, Sameer A.

AU - Mian, Matthew

AU - Bick, Sarah K.

AU - Yang, Jimmy C.

AU - Flaherty, Alice W.

AU - Frank, Michael J.

AU - Widge, Alik S.

AU - Dougherty, Darin

AU - Eskandar, Emad N.

PY - 2018/9

Y1 - 2018/9

N2 - The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

AB - The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

UR - http://www.scopus.com/inward/record.url?scp=85054431049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054431049&partnerID=8YFLogxK

U2 - 10.7554/eLife.36460

DO - 10.7554/eLife.36460

M3 - Article

C2 - 30198482

AN - SCOPUS:85054431049

SN - 2050-084X

VL - 7

JO - eLife

JF - eLife

M1 - e36460

ER -

Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this