Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

Shaun R. Patel, Todd M. Herrington, Sameer A. Sheth, Matthew Mian, Sarah K. Bick, Jimmy C. Yang, Alice W. Flaherty, Michael J. Frank, Alik S. Widge, Darin Dougherty, Emad N. Eskandar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

Original languageEnglish (US)
JournaleLife
Volume7
DOIs
StatePublished - Sep 10 2018
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Brain
Decision making
Neurons
Uncertainty
Decision Making
Basal Ganglia
Cognition

Keywords

  • decision-making
  • deep brain stimulation
  • fMRI
  • human
  • neurophysiology
  • neuroscience
  • subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects. / Patel, Shaun R.; Herrington, Todd M.; Sheth, Sameer A.; Mian, Matthew; Bick, Sarah K.; Yang, Jimmy C.; Flaherty, Alice W.; Frank, Michael J.; Widge, Alik S.; Dougherty, Darin; Eskandar, Emad N.

In: eLife, Vol. 7, 10.09.2018.

Research output: Contribution to journalArticle

Patel, SR, Herrington, TM, Sheth, SA, Mian, M, Bick, SK, Yang, JC, Flaherty, AW, Frank, MJ, Widge, AS, Dougherty, D & Eskandar, EN 2018, 'Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects', eLife, vol. 7. https://doi.org/10.7554/eLife.36460
Patel, Shaun R. ; Herrington, Todd M. ; Sheth, Sameer A. ; Mian, Matthew ; Bick, Sarah K. ; Yang, Jimmy C. ; Flaherty, Alice W. ; Frank, Michael J. ; Widge, Alik S. ; Dougherty, Darin ; Eskandar, Emad N. / Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects. In: eLife. 2018 ; Vol. 7.
@article{577826e434e3405ab36c814fe3aea611,
title = "Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects",
abstract = "The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.",
keywords = "decision-making, deep brain stimulation, fMRI, human, neurophysiology, neuroscience, subthalamic nucleus",
author = "Patel, {Shaun R.} and Herrington, {Todd M.} and Sheth, {Sameer A.} and Matthew Mian and Bick, {Sarah K.} and Yang, {Jimmy C.} and Flaherty, {Alice W.} and Frank, {Michael J.} and Widge, {Alik S.} and Darin Dougherty and Eskandar, {Emad N.}",
year = "2018",
month = "9",
day = "10",
doi = "10.7554/eLife.36460",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

AU - Patel, Shaun R.

AU - Herrington, Todd M.

AU - Sheth, Sameer A.

AU - Mian, Matthew

AU - Bick, Sarah K.

AU - Yang, Jimmy C.

AU - Flaherty, Alice W.

AU - Frank, Michael J.

AU - Widge, Alik S.

AU - Dougherty, Darin

AU - Eskandar, Emad N.

PY - 2018/9/10

Y1 - 2018/9/10

N2 - The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

AB - The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

KW - decision-making

KW - deep brain stimulation

KW - fMRI

KW - human

KW - neurophysiology

KW - neuroscience

KW - subthalamic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85054431049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054431049&partnerID=8YFLogxK

U2 - 10.7554/eLife.36460

DO - 10.7554/eLife.36460

M3 - Article

C2 - 30198482

AN - SCOPUS:85054431049

VL - 7

JO - eLife

JF - eLife

SN - 2050-084X

ER -