Intensity-modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation: Initial report

Ajay K. Bhatnagar, Edward Brandner, Deborah Sonnik, Andrew Wu, Shalom Kalnicki, Melvin Deutsch, Dwight E. Heron

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

PURPOSE: This study was designed to compare the dose received by the contralateral breast during primary breast irradiation using intensity-modulated radiotherapy with the dose received via conventional tangential field techniques. METHODS/MATERIALS: Between March 2003 and March 2004, 44 patients with breast carcinoma were treated using 6-, 10-, or mixed 6/18-MV photons (36 with tangential intensity-modulated radiotherapy technique and eight with three-dimensional technique using tangential fields with wedges) for primary breast irradiation after breast-conserving surgery. Paired thermoluminescent dosimeters were placed on each patient's contralateral breast, 4 cm from the center of the medial border of the tangential field. The thermoluminescent dosimeters were left on the patient during a single fraction and then measured 24 hours later. RESULTS: The mean dose delivered with photons to the primary breast for all patients was 4998 cGy [SD = 52], and the mean single fraction dose was 200 cGy [SD = 9]. The mean percent of the prescribed dose to the contralateral breast was 7.74% (SD = 2.35) for patients treated with intensity-modulated radiotherapy, compared with 9.74% [SD = 2.04] for the patients treated with conventional tangential field techniques. This represented a 20% reduction in the mean dose to the contralateral breast with the use of intensity-modulated radiotherapy when compared with the dose received via the three-dimensional technique, a result that was statistically significant. CONCLUSION: Primary breast irradiation with tangential intensity-modulated radiotherapy technique significantly reduces the dose to the contralateral breast when compared with conventional tangential techniques.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalCancer Journal
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Keywords

  • Breast cancer
  • Contralateral breast dose
  • Intensity-modulated radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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