Integrin signalling during tumour progression

Wenjun Guo, Filippo G. Giancotti

Research output: Contribution to journalArticle

1056 Citations (Scopus)

Abstract

During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs.

Original languageEnglish (US)
Pages (from-to)816-826
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume5
Issue number10
DOIs
StatePublished - Oct 2004

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Integrins
Receptor Protein-Tyrosine Kinases
Neoplasms
Neoplasm Metastasis
Gene Amplification
Mutation
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Integrin signalling during tumour progression. / Guo, Wenjun; Giancotti, Filippo G.

In: Nature Reviews Molecular Cell Biology, Vol. 5, No. 10, 10.2004, p. 816-826.

Research output: Contribution to journalArticle

Guo, Wenjun ; Giancotti, Filippo G. / Integrin signalling during tumour progression. In: Nature Reviews Molecular Cell Biology. 2004 ; Vol. 5, No. 10. pp. 816-826.
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