Integrative erectile biology: The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction

Arnold Melman, George J. Christ

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Initiation, maintenance, and modulation of corporal smooth muscle tone are critically dependent upon agonist-induced changes in intracellular calcium levels and mobilization as well as transmembrane calcium flux. The transient control of myocyte excitability and contractility at the cellular level is inextricably linked to membrane potenial, which, in turn, is modulated by potassium ion efflux through one of the four known corporeal smooth muscle potassium ion channels. Corporal tissue responses are subsequently coordinated by means of the movement of intracellular second messenger molecules (i.e., IP3, cAMP, cGMP) and ions (i.e., K+ and Ca2+) among the corporal myocytes by means of intracellular communication through gap junction channels. Knowledge of the critical contribution of these interlinking cellular (nonjunctional ion channels [e.g., maxi-K]) and tissue (gap junction channels [e.g., connexin 43]) systems to the modulation of erectile capacity has provided the scientific rationale for the promulgation of the successful preclinical testing of hSlo ion channel gene therapy for the normalization of erectile status in both aged and diabetic rats.

Original languageEnglish (US)
Pages (from-to)217-232
Number of pages16
JournalUrologic Clinics of North America
Volume28
Issue number2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Urology

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