Influence of left ventricular function on survival and mode of death after implantable defibrillator therapy (Cleveland Clinic Foundation and Montefiore Medical Center experience)

Soo G. Kim, James D. Maloney, Sergio L. Pinski, Chung Whee Choue, Kevin J. Ferrick, James A. Roth, Jay N. Gross, Richard Brodman, Seymour Furman, John Devens Fisher

Research output: Contribution to journalArticle

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Abstract

To determine the influence of left ventricular (LV) function on survival and mode of death in patients with an implantable cardioverter-defibrillator (ICD), sudden death, surgical mortality, total arrhythmia-related death, total cardiac death and total death were retrospectively evaluated in 377 consecutive patients. The outcomes were also compared between patients with an LV ejection fraction ≥30% (214 patients, group 1) and <30% (148 patients, group 2). Surgical mortality was 3.9% (1.8% in group 1, 7% in group 2). During the follow-up of 25 ± 20 months, actuarial survival rates of all patients at 3 years were 96% for sudden deaths, 81% for total cardiac deaths and 74% for total mortality. When the 2 groups were compared, survival rates of groups 1 and 2 at 3 years, respectively, were 99 and 90% for sudden death (p < 0.05), 97 and 84% for sudden death and surgical mortality (p < 0.01), 94 and 80% for the total arrhythmia-related death (p < 0.001), 88 and 68% for total cardiac death (p < 0.0001), and 81 and 62% for total mortality (p < 0.002). In group 2, 73% of total cardiac deaths within 1 year were causally related to the arrhythmia. Thus, in patients with an ICD, sudden death rates were very low. However, total cardiac death and total death rates were relatively higher. The outcomes of patients with an ICD were strongly influenced by the degree of LV dysfunction. In group 2 patients, although the sudden death rate was relatively low (10% at 3 years), surgical mortality rate, total cardiac death rate and total mortality rate were substantial. A significant majority of total cardiac deaths were causally related to the arrhythmia.

Original languageEnglish (US)
Pages (from-to)1263-1267
Number of pages5
JournalThe American Journal of Cardiology
Volume72
Issue number17
DOIs
StatePublished - Dec 1 1993

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Implantable Defibrillators
Left Ventricular Function
Survival
Mortality
Sudden Death
Cardiac Arrhythmias
Therapeutics
Survival Rate
Left Ventricular Dysfunction
Stroke Volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Influence of left ventricular function on survival and mode of death after implantable defibrillator therapy (Cleveland Clinic Foundation and Montefiore Medical Center experience). / Kim, Soo G.; Maloney, James D.; Pinski, Sergio L.; Choue, Chung Whee; Ferrick, Kevin J.; Roth, James A.; Gross, Jay N.; Brodman, Richard; Furman, Seymour; Fisher, John Devens.

In: The American Journal of Cardiology, Vol. 72, No. 17, 01.12.1993, p. 1263-1267.

Research output: Contribution to journalArticle

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abstract = "To determine the influence of left ventricular (LV) function on survival and mode of death in patients with an implantable cardioverter-defibrillator (ICD), sudden death, surgical mortality, total arrhythmia-related death, total cardiac death and total death were retrospectively evaluated in 377 consecutive patients. The outcomes were also compared between patients with an LV ejection fraction ≥30{\%} (214 patients, group 1) and <30{\%} (148 patients, group 2). Surgical mortality was 3.9{\%} (1.8{\%} in group 1, 7{\%} in group 2). During the follow-up of 25 ± 20 months, actuarial survival rates of all patients at 3 years were 96{\%} for sudden deaths, 81{\%} for total cardiac deaths and 74{\%} for total mortality. When the 2 groups were compared, survival rates of groups 1 and 2 at 3 years, respectively, were 99 and 90{\%} for sudden death (p < 0.05), 97 and 84{\%} for sudden death and surgical mortality (p < 0.01), 94 and 80{\%} for the total arrhythmia-related death (p < 0.001), 88 and 68{\%} for total cardiac death (p < 0.0001), and 81 and 62{\%} for total mortality (p < 0.002). In group 2, 73{\%} of total cardiac deaths within 1 year were causally related to the arrhythmia. Thus, in patients with an ICD, sudden death rates were very low. However, total cardiac death and total death rates were relatively higher. The outcomes of patients with an ICD were strongly influenced by the degree of LV dysfunction. In group 2 patients, although the sudden death rate was relatively low (10{\%} at 3 years), surgical mortality rate, total cardiac death rate and total mortality rate were substantial. A significant majority of total cardiac deaths were causally related to the arrhythmia.",
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