Infectious diarrhea in patients with AIDS

Michael A. Antony, Lawrence J. Brandt, Robert S. Klein, Leslie H. Bernstein

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are lacking. We reviewed the records of 100 patients with AIDS and assessed the frequency and organisms causing infectious diarrhea. We found diarrhea to be more common in homosexuals (80%) than heterosexuals with a risk factor of parenteral drug use (58%). In one third of all cases, no infectious etiology was found. Myobacterium avium intracellulare (MAI) was the most commonly identified cause of infectious diarrhea in our series, followed by cytomegalovirus, cryptosporidium, Salmonella spp., and herpes virus. In addition, bacteremia was documented in 43% of patients with infectious diarrhea and was most commonly due to MAI. Finally, we demonstrated that multiple concurrent infections are not uncommon (22%) in AIDS patients and that the diarrheal syndrome may not respond unless all pathogens are eradicated.

Original languageEnglish (US)
Pages (from-to)1141-1146
Number of pages6
JournalDigestive Diseases and Sciences
Volume33
Issue number9
DOIs
StatePublished - Sep 1988

Fingerprint

Diarrhea
Acquired Immunodeficiency Syndrome
Cryptosporidium
Heterosexuality
Opportunistic Infections
Bacteremia
Infection
Cytomegalovirus
Salmonella
Gastrointestinal Tract
Viruses
Pharmaceutical Preparations

Keywords

  • acquired immunodeficiency syndrome
  • homosexuality
  • infectious diarrhea
  • intravenous drug abuse
  • opportunistic infections

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Infectious diarrhea in patients with AIDS. / Antony, Michael A.; Brandt, Lawrence J.; Klein, Robert S.; Bernstein, Leslie H.

In: Digestive Diseases and Sciences, Vol. 33, No. 9, 09.1988, p. 1141-1146.

Research output: Contribution to journalArticle

Antony, MA, Brandt, LJ, Klein, RS & Bernstein, LH 1988, 'Infectious diarrhea in patients with AIDS', Digestive Diseases and Sciences, vol. 33, no. 9, pp. 1141-1146. https://doi.org/10.1007/BF01535791
Antony, Michael A. ; Brandt, Lawrence J. ; Klein, Robert S. ; Bernstein, Leslie H. / Infectious diarrhea in patients with AIDS. In: Digestive Diseases and Sciences. 1988 ; Vol. 33, No. 9. pp. 1141-1146.
@article{4584345fe8034e189c1e84b63bb999d8,
title = "Infectious diarrhea in patients with AIDS",
abstract = "A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are lacking. We reviewed the records of 100 patients with AIDS and assessed the frequency and organisms causing infectious diarrhea. We found diarrhea to be more common in homosexuals (80{\%}) than heterosexuals with a risk factor of parenteral drug use (58{\%}). In one third of all cases, no infectious etiology was found. Myobacterium avium intracellulare (MAI) was the most commonly identified cause of infectious diarrhea in our series, followed by cytomegalovirus, cryptosporidium, Salmonella spp., and herpes virus. In addition, bacteremia was documented in 43{\%} of patients with infectious diarrhea and was most commonly due to MAI. Finally, we demonstrated that multiple concurrent infections are not uncommon (22{\%}) in AIDS patients and that the diarrheal syndrome may not respond unless all pathogens are eradicated.",
keywords = "acquired immunodeficiency syndrome, homosexuality, infectious diarrhea, intravenous drug abuse, opportunistic infections",
author = "Antony, {Michael A.} and Brandt, {Lawrence J.} and Klein, {Robert S.} and Bernstein, {Leslie H.}",
year = "1988",
month = "9",
doi = "10.1007/BF01535791",
language = "English (US)",
volume = "33",
pages = "1141--1146",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "9",

}

TY - JOUR

T1 - Infectious diarrhea in patients with AIDS

AU - Antony, Michael A.

AU - Brandt, Lawrence J.

AU - Klein, Robert S.

AU - Bernstein, Leslie H.

PY - 1988/9

Y1 - 1988/9

N2 - A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are lacking. We reviewed the records of 100 patients with AIDS and assessed the frequency and organisms causing infectious diarrhea. We found diarrhea to be more common in homosexuals (80%) than heterosexuals with a risk factor of parenteral drug use (58%). In one third of all cases, no infectious etiology was found. Myobacterium avium intracellulare (MAI) was the most commonly identified cause of infectious diarrhea in our series, followed by cytomegalovirus, cryptosporidium, Salmonella spp., and herpes virus. In addition, bacteremia was documented in 43% of patients with infectious diarrhea and was most commonly due to MAI. Finally, we demonstrated that multiple concurrent infections are not uncommon (22%) in AIDS patients and that the diarrheal syndrome may not respond unless all pathogens are eradicated.

AB - A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are lacking. We reviewed the records of 100 patients with AIDS and assessed the frequency and organisms causing infectious diarrhea. We found diarrhea to be more common in homosexuals (80%) than heterosexuals with a risk factor of parenteral drug use (58%). In one third of all cases, no infectious etiology was found. Myobacterium avium intracellulare (MAI) was the most commonly identified cause of infectious diarrhea in our series, followed by cytomegalovirus, cryptosporidium, Salmonella spp., and herpes virus. In addition, bacteremia was documented in 43% of patients with infectious diarrhea and was most commonly due to MAI. Finally, we demonstrated that multiple concurrent infections are not uncommon (22%) in AIDS patients and that the diarrheal syndrome may not respond unless all pathogens are eradicated.

KW - acquired immunodeficiency syndrome

KW - homosexuality

KW - infectious diarrhea

KW - intravenous drug abuse

KW - opportunistic infections

UR - http://www.scopus.com/inward/record.url?scp=0023735242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023735242&partnerID=8YFLogxK

U2 - 10.1007/BF01535791

DO - 10.1007/BF01535791

M3 - Article

VL - 33

SP - 1141

EP - 1146

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 9

ER -