Infectious diarrhea in patients with AIDS

Michael A. Antony, Lawrence J. Brandt, Robert S. Klein, Leslie H. Bernstein

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

A multitude of opportunistic infections has been documented in virtually every organ system of patients with the acquired immunodeficiency syndrome (AIDS). Prominent among these are infections of the gastrointestinal tract. However, studies of large numbers of patients documenting the frequency of such involvement are lacking. We reviewed the records of 100 patients with AIDS and assessed the frequency and organisms causing infectious diarrhea. We found diarrhea to be more common in homosexuals (80%) than heterosexuals with a risk factor of parenteral drug use (58%). In one third of all cases, no infectious etiology was found. Myobacterium avium intracellulare (MAI) was the most commonly identified cause of infectious diarrhea in our series, followed by cytomegalovirus, cryptosporidium, Salmonella spp., and herpes virus. In addition, bacteremia was documented in 43% of patients with infectious diarrhea and was most commonly due to MAI. Finally, we demonstrated that multiple concurrent infections are not uncommon (22%) in AIDS patients and that the diarrheal syndrome may not respond unless all pathogens are eradicated.

Original languageEnglish (US)
Pages (from-to)1141-1146
Number of pages6
JournalDigestive Diseases and Sciences
Volume33
Issue number9
DOIs
StatePublished - Sep 1 1988

Keywords

  • acquired immunodeficiency syndrome
  • homosexuality
  • infectious diarrhea
  • intravenous drug abuse
  • opportunistic infections

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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