Infections and Immune Thrombocytopenic Purpura

Alexander Ja-Ho Chou, James Bussel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immune thrombocytopenic purpura (ITP) is an idiopathic disease defined by a low platelet count in the absence of other causes of thrombocytopenia such as malignancy, disseminated intravascular coagulation, or medication-induced thrombocytopenia. It is an (auto) immune-mediated disorder that affects both adults and children, although their clinical manifestations can be very different. The understanding of the pathophysiology of ITP has advanced dramatically since the first in vivo experiments were conducted by Dr. Harfington more than 50 years ago. Yet, much still needs to be learned about this interestingly diverse disease. Though it is known that auto-antibodies are made against platelet antigens, the initial trigger for antibody production is still unclear. Other issues that warrant further investigation include the mechanisms through which viruses initiate or maintain the disease process in ITP; this would have to take into account individual susceptibility factors (that is, genes). Other areas to be further elucidated include the role of inflammatory and anti-inflammatory cytokines, and mechanisms through which autoreactive immune cells escape negative selection by the developing immune system. The interaction between the immune system and infectious agents in the pathophysiology of ITP will remain a critical point of investigation.

Original languageEnglish (US)
Title of host publicationInfection and Autoimmunity, 2nd edition
PublisherElsevier
Pages637-647
Number of pages11
ISBN (Print)9780444512710
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Idiopathic Thrombocytopenic Purpura
Infection
Thrombocytopenia
Immune System
Disseminated Intravascular Coagulation
Immune System Diseases
Platelet Count
Antibody Formation
Anti-Inflammatory Agents
Blood Platelets
Cytokines
Viruses
Antigens
Antibodies
Genes
Neoplasms

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Chou, A. J-H., & Bussel, J. (2004). Infections and Immune Thrombocytopenic Purpura. In Infection and Autoimmunity, 2nd edition (pp. 637-647). Elsevier. https://doi.org/10.1016/B978-044451271-0.50050-8

Infections and Immune Thrombocytopenic Purpura. / Chou, Alexander Ja-Ho; Bussel, James.

Infection and Autoimmunity, 2nd edition. Elsevier, 2004. p. 637-647.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chou, AJ-H & Bussel, J 2004, Infections and Immune Thrombocytopenic Purpura. in Infection and Autoimmunity, 2nd edition. Elsevier, pp. 637-647. https://doi.org/10.1016/B978-044451271-0.50050-8
Chou AJ-H, Bussel J. Infections and Immune Thrombocytopenic Purpura. In Infection and Autoimmunity, 2nd edition. Elsevier. 2004. p. 637-647 https://doi.org/10.1016/B978-044451271-0.50050-8
Chou, Alexander Ja-Ho ; Bussel, James. / Infections and Immune Thrombocytopenic Purpura. Infection and Autoimmunity, 2nd edition. Elsevier, 2004. pp. 637-647
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