Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases

Xin Liu; Yue Zhao; Catherine Luedke; Rachel Jug; Lian He Yang; Mark Lu; Zenggang Pan; Dehua Wang; Robert Lorsbach; Yang Shi; Virginia Knez; Catherine Rehder; Xiayuan Liang; Endi Wang

doi:10.1111/ijlh.13540

Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases

Xin Liu, Yue Zhao, Catherine Luedke, Rachel Jug, Lian He Yang, Mark Lu, Zenggang Pan, Dehua Wang, Robert Lorsbach, Yang Shi, Virginia Knez, Catherine Rehder, Xiayuan Liang, Endi Wang

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection. Methods: We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data. Results: Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 1:2, with a better survival for AML than B-ALL (median survival 36 vs 24 months). When stratified by age, “early” infantile B-ALL (2-6 months) showed a high rate of KMT2A rearrangement (100%), similar to the rate seen in congenital B-ALL (1 month) (100%) and higher than seen in “late” infantile B-ALL (≥7 months) (68%). The three categories of infantile B-ALL exhibited an age-dependent increase in survival (median survival 8.5, 24, and >24 months, respectively). The age-dependent survival benefit remained after excluding the cases negative for KMT2A rearrangement. Conversely, infantile AML lacked an age-dependent pattern of survival. Conclusion: The clinical outcome of infantile leukemia depends on the type of leukemia. Given the age-dependent survival, infantile B-ALL can be divided into three subcategories.

Original language	English (US)
Pages (from-to)	1117-1122
Number of pages	6
Journal	International Journal of Laboratory Hematology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1111/ijlh.13540
State	Published - Oct 2021

Keywords

B-lymphoblastic leukemia
acute myeloid leukemia
congenital leukemia
infantile leukemia

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Biochemistry, medical

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10.1111/ijlh.13540

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Liu, X., Zhao, Y., Luedke, C., Jug, R., Yang, L. H., Lu, M., Pan, Z., Wang, D., Lorsbach, R., Shi, Y., Knez, V., Rehder, C., Liang, X., & Wang, E. (2021). Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases. International Journal of Laboratory Hematology, 43(5), 1117-1122. https://doi.org/10.1111/ijlh.13540

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title = "Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases",

abstract = "Introduction: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection. Methods: We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data. Results: Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 1:2, with a better survival for AML than B-ALL (median survival 36 vs 24 months). When stratified by age, “early” infantile B-ALL (2-6 months) showed a high rate of KMT2A rearrangement (100%), similar to the rate seen in congenital B-ALL (1 month) (100%) and higher than seen in “late” infantile B-ALL (≥7 months) (68%). The three categories of infantile B-ALL exhibited an age-dependent increase in survival (median survival 8.5, 24, and >24 months, respectively). The age-dependent survival benefit remained after excluding the cases negative for KMT2A rearrangement. Conversely, infantile AML lacked an age-dependent pattern of survival. Conclusion: The clinical outcome of infantile leukemia depends on the type of leukemia. Given the age-dependent survival, infantile B-ALL can be divided into three subcategories.",

keywords = "B-lymphoblastic leukemia, acute myeloid leukemia, congenital leukemia, infantile leukemia",

author = "Xin Liu and Yue Zhao and Catherine Luedke and Rachel Jug and Yang, {Lian He} and Mark Lu and Zenggang Pan and Dehua Wang and Robert Lorsbach and Yang Shi and Virginia Knez and Catherine Rehder and Xiayuan Liang and Endi Wang",

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year = "2021",

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doi = "10.1111/ijlh.13540",

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volume = "43",

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T1 - Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases

AU - Liu, Xin

AU - Zhao, Yue

AU - Luedke, Catherine

AU - Jug, Rachel

AU - Yang, Lian He

AU - Lu, Mark

AU - Pan, Zenggang

AU - Wang, Dehua

AU - Lorsbach, Robert

AU - Shi, Yang

AU - Knez, Virginia

AU - Rehder, Catherine

AU - Liang, Xiayuan

AU - Wang, Endi

PY - 2021/10

Y1 - 2021/10

N2 - Introduction: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection. Methods: We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data. Results: Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 1:2, with a better survival for AML than B-ALL (median survival 36 vs 24 months). When stratified by age, “early” infantile B-ALL (2-6 months) showed a high rate of KMT2A rearrangement (100%), similar to the rate seen in congenital B-ALL (1 month) (100%) and higher than seen in “late” infantile B-ALL (≥7 months) (68%). The three categories of infantile B-ALL exhibited an age-dependent increase in survival (median survival 8.5, 24, and >24 months, respectively). The age-dependent survival benefit remained after excluding the cases negative for KMT2A rearrangement. Conversely, infantile AML lacked an age-dependent pattern of survival. Conclusion: The clinical outcome of infantile leukemia depends on the type of leukemia. Given the age-dependent survival, infantile B-ALL can be divided into three subcategories.

AB - Introduction: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection. Methods: We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data. Results: Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 1:2, with a better survival for AML than B-ALL (median survival 36 vs 24 months). When stratified by age, “early” infantile B-ALL (2-6 months) showed a high rate of KMT2A rearrangement (100%), similar to the rate seen in congenital B-ALL (1 month) (100%) and higher than seen in “late” infantile B-ALL (≥7 months) (68%). The three categories of infantile B-ALL exhibited an age-dependent increase in survival (median survival 8.5, 24, and >24 months, respectively). The age-dependent survival benefit remained after excluding the cases negative for KMT2A rearrangement. Conversely, infantile AML lacked an age-dependent pattern of survival. Conclusion: The clinical outcome of infantile leukemia depends on the type of leukemia. Given the age-dependent survival, infantile B-ALL can be divided into three subcategories.

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KW - acute myeloid leukemia

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Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases

Abstract

Keywords

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