Induction of thyroid autoantibodies in naive mice by idiotypic manipulation

Yaron Tomer, Boris Gilburd, Joseph Sack, Terry F. Davies, Asher Meshorer, C. Lynne Burek, Noel R. Rose, Yehuda Shoenfeld

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Previously, we have shown that it is possible to induce, in naive mice, systemic autoimmune diseases (e.g., antiphospholipid syndrome and systemic lupus erythematosus) by idiotypic manipulation. In the present study we expanded our experience to examine whether idiotypic manipulation could be utilized to induce organ-specific autoantibodies and a disease mediated by cellular mechanisms, namely, experimental autoimmune thyroiditis. Fifteen BALB/c mice were immunized with a monoclonal mouse anti-human thyroglobulin (hTg) antibody; controls were immunized with an irrelevant mouse IgG. The mice immunized with anti-hTg antibody developed, 6 weeks after immunization, autoantibodies to human thyroglobulin, but not to dsDNA, cardiolipin, or myeloperoxidase. The presence of specific autoantibodies was associated with low production of thyroid hormones, and during a follow-up of 20 weeks the mice did not develop characteristic histological signs of thyroiditis. We conclude that idiotypic manipulation can induce anti-thyroglobulin autoantibodies.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalClinical Immunology and Immunopathology
Volume78
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Autoantibodies
Thyroid Gland
Autoimmune Thyroiditis
Thyroiditis
Cardiolipins
Antiphospholipid Syndrome
Thyroglobulin
Thyroid Hormones
Systemic Lupus Erythematosus
Peroxidase
Autoimmune Diseases
Immunization
Immunoglobulin G
anti-thyroglobulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pathology and Forensic Medicine

Cite this

Tomer, Y., Gilburd, B., Sack, J., Davies, T. F., Meshorer, A., Burek, C. L., ... Shoenfeld, Y. (1996). Induction of thyroid autoantibodies in naive mice by idiotypic manipulation. Clinical Immunology and Immunopathology, 78(2), 180-187. https://doi.org/10.1006/clin.1996.0027

Induction of thyroid autoantibodies in naive mice by idiotypic manipulation. / Tomer, Yaron; Gilburd, Boris; Sack, Joseph; Davies, Terry F.; Meshorer, Asher; Burek, C. Lynne; Rose, Noel R.; Shoenfeld, Yehuda.

In: Clinical Immunology and Immunopathology, Vol. 78, No. 2, 1996, p. 180-187.

Research output: Contribution to journalArticle

Tomer, Y, Gilburd, B, Sack, J, Davies, TF, Meshorer, A, Burek, CL, Rose, NR & Shoenfeld, Y 1996, 'Induction of thyroid autoantibodies in naive mice by idiotypic manipulation', Clinical Immunology and Immunopathology, vol. 78, no. 2, pp. 180-187. https://doi.org/10.1006/clin.1996.0027
Tomer, Yaron ; Gilburd, Boris ; Sack, Joseph ; Davies, Terry F. ; Meshorer, Asher ; Burek, C. Lynne ; Rose, Noel R. ; Shoenfeld, Yehuda. / Induction of thyroid autoantibodies in naive mice by idiotypic manipulation. In: Clinical Immunology and Immunopathology. 1996 ; Vol. 78, No. 2. pp. 180-187.
@article{27894d1cdd90449d9fddf7d04817c2ee,
title = "Induction of thyroid autoantibodies in naive mice by idiotypic manipulation",
abstract = "Previously, we have shown that it is possible to induce, in naive mice, systemic autoimmune diseases (e.g., antiphospholipid syndrome and systemic lupus erythematosus) by idiotypic manipulation. In the present study we expanded our experience to examine whether idiotypic manipulation could be utilized to induce organ-specific autoantibodies and a disease mediated by cellular mechanisms, namely, experimental autoimmune thyroiditis. Fifteen BALB/c mice were immunized with a monoclonal mouse anti-human thyroglobulin (hTg) antibody; controls were immunized with an irrelevant mouse IgG. The mice immunized with anti-hTg antibody developed, 6 weeks after immunization, autoantibodies to human thyroglobulin, but not to dsDNA, cardiolipin, or myeloperoxidase. The presence of specific autoantibodies was associated with low production of thyroid hormones, and during a follow-up of 20 weeks the mice did not develop characteristic histological signs of thyroiditis. We conclude that idiotypic manipulation can induce anti-thyroglobulin autoantibodies.",
author = "Yaron Tomer and Boris Gilburd and Joseph Sack and Davies, {Terry F.} and Asher Meshorer and Burek, {C. Lynne} and Rose, {Noel R.} and Yehuda Shoenfeld",
year = "1996",
doi = "10.1006/clin.1996.0027",
language = "English (US)",
volume = "78",
pages = "180--187",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Induction of thyroid autoantibodies in naive mice by idiotypic manipulation

AU - Tomer, Yaron

AU - Gilburd, Boris

AU - Sack, Joseph

AU - Davies, Terry F.

AU - Meshorer, Asher

AU - Burek, C. Lynne

AU - Rose, Noel R.

AU - Shoenfeld, Yehuda

PY - 1996

Y1 - 1996

N2 - Previously, we have shown that it is possible to induce, in naive mice, systemic autoimmune diseases (e.g., antiphospholipid syndrome and systemic lupus erythematosus) by idiotypic manipulation. In the present study we expanded our experience to examine whether idiotypic manipulation could be utilized to induce organ-specific autoantibodies and a disease mediated by cellular mechanisms, namely, experimental autoimmune thyroiditis. Fifteen BALB/c mice were immunized with a monoclonal mouse anti-human thyroglobulin (hTg) antibody; controls were immunized with an irrelevant mouse IgG. The mice immunized with anti-hTg antibody developed, 6 weeks after immunization, autoantibodies to human thyroglobulin, but not to dsDNA, cardiolipin, or myeloperoxidase. The presence of specific autoantibodies was associated with low production of thyroid hormones, and during a follow-up of 20 weeks the mice did not develop characteristic histological signs of thyroiditis. We conclude that idiotypic manipulation can induce anti-thyroglobulin autoantibodies.

AB - Previously, we have shown that it is possible to induce, in naive mice, systemic autoimmune diseases (e.g., antiphospholipid syndrome and systemic lupus erythematosus) by idiotypic manipulation. In the present study we expanded our experience to examine whether idiotypic manipulation could be utilized to induce organ-specific autoantibodies and a disease mediated by cellular mechanisms, namely, experimental autoimmune thyroiditis. Fifteen BALB/c mice were immunized with a monoclonal mouse anti-human thyroglobulin (hTg) antibody; controls were immunized with an irrelevant mouse IgG. The mice immunized with anti-hTg antibody developed, 6 weeks after immunization, autoantibodies to human thyroglobulin, but not to dsDNA, cardiolipin, or myeloperoxidase. The presence of specific autoantibodies was associated with low production of thyroid hormones, and during a follow-up of 20 weeks the mice did not develop characteristic histological signs of thyroiditis. We conclude that idiotypic manipulation can induce anti-thyroglobulin autoantibodies.

UR - http://www.scopus.com/inward/record.url?scp=0029864966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029864966&partnerID=8YFLogxK

U2 - 10.1006/clin.1996.0027

DO - 10.1006/clin.1996.0027

M3 - Article

C2 - 8625560

AN - SCOPUS:0029864966

VL - 78

SP - 180

EP - 187

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -