Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D1 receptor stimulation

Takeshi Hiramoto, Yasushi Satoh, Kunio Takishima, Yasuhiro Watanabe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of α-1 adrenergic receptors. Our results suggest that α-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.

Original languageEnglish (US)
Pages (from-to)793-797
Number of pages5
JournalNeuroReport
Volume19
Issue number8
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Adrenergic alpha-1 Receptors
Dopamine D1 Receptors
Cell Movement
Stem Cells
Epinephrine
Adrenergic Receptors
Dopamine
Telencephalon
Dopamine Agonists
Cerebral Cortex
Embryonic Development
Neurotransmitter Agents
In Vitro Techniques
Brain

Keywords

  • α-1 adrenergic receptors
  • Cell migration
  • Dopamine D receptors
  • L-adrenaline
  • L-dopamine
  • Neural progenitor cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D1 receptor stimulation. / Hiramoto, Takeshi; Satoh, Yasushi; Takishima, Kunio; Watanabe, Yasuhiro.

In: NeuroReport, Vol. 19, No. 8, 05.2008, p. 793-797.

Research output: Contribution to journalArticle

@article{49fc4a51ff284c5da1e4f48d19093ac1,
title = "Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D1 receptor stimulation",
abstract = "The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of α-1 adrenergic receptors. Our results suggest that α-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.",
keywords = "α-1 adrenergic receptors, Cell migration, Dopamine D receptors, L-adrenaline, L-dopamine, Neural progenitor cells",
author = "Takeshi Hiramoto and Yasushi Satoh and Kunio Takishima and Yasuhiro Watanabe",
year = "2008",
month = "5",
doi = "10.1097/WNR.0b013e3282fd1270",
language = "English (US)",
volume = "19",
pages = "793--797",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D1 receptor stimulation

AU - Hiramoto, Takeshi

AU - Satoh, Yasushi

AU - Takishima, Kunio

AU - Watanabe, Yasuhiro

PY - 2008/5

Y1 - 2008/5

N2 - The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of α-1 adrenergic receptors. Our results suggest that α-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.

AB - The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of α-1 adrenergic receptors. Our results suggest that α-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.

KW - α-1 adrenergic receptors

KW - Cell migration

KW - Dopamine D receptors

KW - L-adrenaline

KW - L-dopamine

KW - Neural progenitor cells

UR - http://www.scopus.com/inward/record.url?scp=43249111076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43249111076&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e3282fd1270

DO - 10.1097/WNR.0b013e3282fd1270

M3 - Article

VL - 19

SP - 793

EP - 797

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 8

ER -