Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways

Shixiang Sun, Ryan R. White, Kathleen E. Fischer, Zhengdong Zhang, Steven N. Austad, Jan Vijg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Freshwater polyps of the genus Hydra do not age. However, temperature stress induces aging and a shift from reproduction by asexual budding to sexual gamete production in a cold-sensitive (CS) strain of H. oligactis. We sequenced the transcriptome of a male CS strain before and after this life history shift and compared changes in gene expression relative to those seen in a cold-resistant (CR) strain that does not undergo a life history shift in response to altered temperature. We found that the switch from non-aging asexual reproduction to aging and sexual reproduction involves upregulation of genes not only involved in gametogenesis but also genes involved in cellular senescence, apoptosis, and DNA repair accompanied by a downregulation of genes involved in stem cell maintenance. These results suggest that aging is a byproduct of sexual reproduction-associated cellular reprogramming and underscore the power of these H. oligactis strains to identify intrinsic mechanisms of aging.

Original languageEnglish (US)
Pages (from-to)1119-1132
Number of pages14
JournalGeroScience
Volume42
Issue number4
DOIs
StatePublished - Aug 1 2020

Keywords

  • Aging
  • Cold-sensitive
  • DNA repair
  • Gametogenesis
  • Hydra oligactis
  • Transcriptome

ASJC Scopus subject areas

  • Aging
  • veterinary (miscalleneous)
  • Complementary and alternative medicine
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine

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