Inducibility of transferrin receptors on friend erythroleukemic cells

Hsiang Yun Yang Hu, Joseph Gardner, Philip Aisen, Arthur I. Skoultchi

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The ability of Friend erythroleukemic cells to bind transferrin and take up its iron increases substantially as a result of dimethyl sulfoxide-stimulated differentiation. Although transferrin-binding activity is also demonstrable in another mouse cell line of hematopoietic origin, the lymphoma cell, it does not increase on exposure to dimethyl sulfoxide. Gel filtration studies corroborate that the binding of transferrin to the erythroleukemic cells is due to the formation of a specific complex of transferrin and a membrane receptor. Thus, the specific interaction of transferrin with its receptor is another expression of dimethyl sulfoxide-induced differentiation in the Friend cell.

Original languageEnglish (US)
Pages (from-to)559-561
Number of pages3
JournalScience
Volume197
Issue number4303
StatePublished - 1977

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Transferrin Receptors
Transferrin
Dimethyl Sulfoxide
Gel Chromatography
Lymphoma
Iron
Cell Line
Membranes

ASJC Scopus subject areas

  • General

Cite this

Hu, H. Y. Y., Gardner, J., Aisen, P., & Skoultchi, A. I. (1977). Inducibility of transferrin receptors on friend erythroleukemic cells. Science, 197(4303), 559-561.

Inducibility of transferrin receptors on friend erythroleukemic cells. / Hu, Hsiang Yun Yang; Gardner, Joseph; Aisen, Philip; Skoultchi, Arthur I.

In: Science, Vol. 197, No. 4303, 1977, p. 559-561.

Research output: Contribution to journalArticle

Hu, HYY, Gardner, J, Aisen, P & Skoultchi, AI 1977, 'Inducibility of transferrin receptors on friend erythroleukemic cells', Science, vol. 197, no. 4303, pp. 559-561.
Hu, Hsiang Yun Yang ; Gardner, Joseph ; Aisen, Philip ; Skoultchi, Arthur I. / Inducibility of transferrin receptors on friend erythroleukemic cells. In: Science. 1977 ; Vol. 197, No. 4303. pp. 559-561.
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