Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study

Christen Besanceney-Webler, Hao Jiang, Tianqing Zheng, Lei Feng, David Soriano Del Amo, Wei Wang, Liana M. Klivansky, Florence L. Marlow, Yi Liu, Peng Wu

Research output: Contribution to journalArticle

232 Scopus citations

Abstract

Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

Original languageEnglish (US)
Pages (from-to)8051-8056
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number35
DOIs
StatePublished - Aug 22 2011

    Fingerprint

Keywords

  • alkynes
  • azides
  • bioconjugation
  • bioorthogonal reactions
  • click chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Besanceney-Webler, C., Jiang, H., Zheng, T., Feng, L., Soriano Del Amo, D., Wang, W., Klivansky, L. M., Marlow, F. L., Liu, Y., & Wu, P. (2011). Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study. Angewandte Chemie - International Edition, 50(35), 8051-8056. https://doi.org/10.1002/anie.201101817