Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study

Christen Besanceney-Webler, Hao Jiang, Tianqing Zheng, Lei Feng, David Soriano Del Amo, Wei Wang, Liana M. Klivansky, Florence L. Marlow, Yi Liu, Peng Wu

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

Original languageEnglish (US)
Pages (from-to)8051-8056
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number35
DOIs
StatePublished - Aug 22 2011

Fingerprint

Alkynes
Azides
Cycloaddition
Copper
Ligands

Keywords

  • alkynes
  • azides
  • bioconjugation
  • bioorthogonal reactions
  • click chemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Besanceney-Webler, C., Jiang, H., Zheng, T., Feng, L., Soriano Del Amo, D., Wang, W., ... Wu, P. (2011). Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study. Angewandte Chemie - International Edition, 50(35), 8051-8056. https://doi.org/10.1002/anie.201101817

Increasing the efficacy of bioorthogonal click reactions for bioconjugation : A comparative study. / Besanceney-Webler, Christen; Jiang, Hao; Zheng, Tianqing; Feng, Lei; Soriano Del Amo, David; Wang, Wei; Klivansky, Liana M.; Marlow, Florence L.; Liu, Yi; Wu, Peng.

In: Angewandte Chemie - International Edition, Vol. 50, No. 35, 22.08.2011, p. 8051-8056.

Research output: Contribution to journalArticle

Besanceney-Webler, C, Jiang, H, Zheng, T, Feng, L, Soriano Del Amo, D, Wang, W, Klivansky, LM, Marlow, FL, Liu, Y & Wu, P 2011, 'Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study', Angewandte Chemie - International Edition, vol. 50, no. 35, pp. 8051-8056. https://doi.org/10.1002/anie.201101817
Besanceney-Webler, Christen ; Jiang, Hao ; Zheng, Tianqing ; Feng, Lei ; Soriano Del Amo, David ; Wang, Wei ; Klivansky, Liana M. ; Marlow, Florence L. ; Liu, Yi ; Wu, Peng. / Increasing the efficacy of bioorthogonal click reactions for bioconjugation : A comparative study. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 35. pp. 8051-8056.
@article{a0bf9943a2f4495397dd8ce03650ec7f,
title = "Increasing the efficacy of bioorthogonal click reactions for bioconjugation: A comparative study",
abstract = "Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.",
keywords = "alkynes, azides, bioconjugation, bioorthogonal reactions, click chemistry",
author = "Christen Besanceney-Webler and Hao Jiang and Tianqing Zheng and Lei Feng and {Soriano Del Amo}, David and Wei Wang and Klivansky, {Liana M.} and Marlow, {Florence L.} and Yi Liu and Peng Wu",
year = "2011",
month = "8",
day = "22",
doi = "10.1002/anie.201101817",
language = "English (US)",
volume = "50",
pages = "8051--8056",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "35",

}

TY - JOUR

T1 - Increasing the efficacy of bioorthogonal click reactions for bioconjugation

T2 - A comparative study

AU - Besanceney-Webler, Christen

AU - Jiang, Hao

AU - Zheng, Tianqing

AU - Feng, Lei

AU - Soriano Del Amo, David

AU - Wang, Wei

AU - Klivansky, Liana M.

AU - Marlow, Florence L.

AU - Liu, Yi

AU - Wu, Peng

PY - 2011/8/22

Y1 - 2011/8/22

N2 - Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

AB - Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.

KW - alkynes

KW - azides

KW - bioconjugation

KW - bioorthogonal reactions

KW - click chemistry

UR - http://www.scopus.com/inward/record.url?scp=80051727754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051727754&partnerID=8YFLogxK

U2 - 10.1002/anie.201101817

DO - 10.1002/anie.201101817

M3 - Article

C2 - 21761519

AN - SCOPUS:80051727754

VL - 50

SP - 8051

EP - 8056

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 35

ER -