Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants

M. A. Matthews, Judy L. Aschner, A. R. Stark, P. E. Moore, J. C. Slaughter, S. Steele, A. Beller, G. L. Milne, O. Settles, O. Chorna, N. L. Maitre

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective:This study examined the association between increased early oxidative stress, measured by F2-isoprostanes (IsoPs), and respiratory morbidity at term equivalent age and neurological impairment at 12 months of corrected age (CA).Study Design:Plasma samples were collected from 136 premature infants on days 14 and 28 after birth. All participants were infants born at ⩽28 weeks of gestational age enrolled into the Prematurity and Respiratory Outcomes Program (PROP) study. Respiratory morbidity was determined at 40 weeks of postmenstrual age (PMA) by the Respiratory Severity Index (RSI), a composite measure of oxygen and pressure support. Neurodevelopmental assessment was performed using the Developmental Assessment of Young Children (DAYC) at 12 months of CA. Multivariable logistic regression models estimated associations between IsoP change, RSI and DAYC scores. Mediation analysis was performed to determine the relationship between IsoPs and later outcomes.Results:Developmental data were available for 121 patients (90% of enrolled) at 12 months. For each 50-unit increase in IsoPs, regression modeling predicted decreases in cognitive, communication and motor scores of −1.9, −1.2 and −2.4 points, respectively (P

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - May 12 2016

Fingerprint

F2-Isoprostanes
Isoprostanes
Premature Infants
Logistic Models
Parturition
Morbidity
Gestational Age
Oxidative Stress
Communication
Outcome Assessment (Health Care)
Oxygen
Pressure

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants. / Matthews, M. A.; Aschner, Judy L.; Stark, A. R.; Moore, P. E.; Slaughter, J. C.; Steele, S.; Beller, A.; Milne, G. L.; Settles, O.; Chorna, O.; Maitre, N. L.

In: Journal of Perinatology, 12.05.2016.

Research output: Contribution to journalArticle

Matthews, M. A. ; Aschner, Judy L. ; Stark, A. R. ; Moore, P. E. ; Slaughter, J. C. ; Steele, S. ; Beller, A. ; Milne, G. L. ; Settles, O. ; Chorna, O. ; Maitre, N. L. / Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants. In: Journal of Perinatology. 2016.
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