Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation

Xu Zhong, H. John Hilton, Gregory J. Gates, Sanja Jelic, Yaakov Stern, Matthew N. Bartels, Ronald E. DeMeersman, Robert C. Basner

Research output: Contribution to journalArticle

255 Citations (Scopus)

Abstract

Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 ± 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total powervery LF) × 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing.

Original languageEnglish (US)
Pages (from-to)2024-2032
Number of pages9
JournalJournal of Applied Physiology
Volume98
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Sleep Deprivation
Baroreflex
Heart Rate
Blood Pressure
Power (Psychology)
Reaction Time
Radial Artery
Executive Function
Manometry
Posture

Keywords

  • Baroreflex
  • Sympathovagal balance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. / Zhong, Xu; Hilton, H. John; Gates, Gregory J.; Jelic, Sanja; Stern, Yaakov; Bartels, Matthew N.; DeMeersman, Ronald E.; Basner, Robert C.

In: Journal of Applied Physiology, Vol. 98, No. 6, 06.2005, p. 2024-2032.

Research output: Contribution to journalArticle

Zhong, Xu ; Hilton, H. John ; Gates, Gregory J. ; Jelic, Sanja ; Stern, Yaakov ; Bartels, Matthew N. ; DeMeersman, Ronald E. ; Basner, Robert C. / Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. In: Journal of Applied Physiology. 2005 ; Vol. 98, No. 6. pp. 2024-2032.
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AU - Zhong, Xu

AU - Hilton, H. John

AU - Gates, Gregory J.

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AU - Stern, Yaakov

AU - Bartels, Matthew N.

AU - DeMeersman, Ronald E.

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AB - Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 ± 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total powervery LF) × 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing.

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