TY - JOUR
T1 - Increased pain sensitivity in migraine and tension-type headache coexistent with low back pain
T2 - A cross-sectional population study
AU - Ashina, S.
AU - Lipton, R. B.
AU - Bendtsen, L.
AU - Hajiyeva, N.
AU - Buse, D. C.
AU - Lyngberg, A. C.
AU - Jensen, R.
N1 - Funding Information:
S. Ashina received honoraria for lecturing and serving as a consultant for Allergan, for serving as a consultant for Amgen and for lecturing for Avanir Pharmaceuticals. R. Lip-ton has received grant support from the National Institutes of Health, the National Headache Foundation and the Migraine Research Fund. He serves as consultant, serves as an advisory board member or has received honoraria from Alder, Allergan, American Headache Society, Autonomic Technologies, Boston Scientific, Bristol Myers Squibb, Cognimed, CoLucid, Eli Lilly, eNeura Therapeutics, Merck, Novartis, Pfizer and Teva, Inc. Lars Bendtsen serves on the scientific advisory board for Biogen. D. Buse has received grant support and honoraria from Allergan, Amgen, Avanir and Eli Lilly, and has received research support funded by Allergan, Alder, Avanir, CoLucid, Dr. Reddy’s, and Labrys via grants to the National
Funding Information:
This population study was supported by grants from the East Denmark Health Science Research Forum, the Danish Medical Association Research Fund, the Danish Health Insurance Foundation, the Danish Hospital Foundation for Medical Research, the Danish Headache Society, the Cool Sorption Foundation, GlaxoSmithKline A/S, Merck Sharp Dohme A/S, Pfizer A/S, Lundbeck Pharma A/S and H. Lundbeck A/S. The funding sources have not been involved in the conduct of the study.
Funding Information:
Funding sources This population study was supported by grants from the East Denmark Health Science Research Forum, the Danish Medical Association Research Fund, the Danish Health Insurance Foundation, the Danish Hospital Foundation for Medical Research, the Danish Headache Society, the Cool Sorption Foundation, GlaxoSmithKline A/S, Merck Sharp Dohme A/S, Pfizer A/S, Lundbeck Pharma A/S and H. Lundbeck A/S. The funding sources have not been involved in the conduct of the study. We thank Nurse Vibeke Thomsen for skilful assistance in conducting clinical examination.
Publisher Copyright:
© 2018 European Pain Federation - EFIC®
PY - 2018/5
Y1 - 2018/5
N2 - Background: Low back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self-reported back pain in persons with and without primary headaches and examined pain sensitivity. Method: A population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self-administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (<15 headache days/month) (EH). A total of 495 had a pericranial total tenderness score (TTS), and 494 had cephalic and extracephalic pressure pain thresholds (PPTs) assessed. Results: Adjusted for age, gender, education and poor self-rated health, 1-year relative frequency of back pain was higher in individuals with CH (82.5%) and EH (80.1%) compared to no headache group (65.7%). In persons with back pain, TTS was higher in CH, (26.3 ± 12.1) than in EH, (18.5 ± 10.0; p < 0.001) and higher in both groups than in those with no headache, 10.8 ± 8.5 (p < 0.001 and p < 0.001, respectively). In persons with back pain, temporalis PPT were lower in CH, 169.3 ± 57.8, than in EH, 225.2 ± 98.1, and in no headache group, 244.3 ± 105.4 (p = 0.02 and p = 0.01, respectively). In persons with back pain, finger PPT were lower in CH, 237.1 ± 106.7, than in EH, 291.3 ± 141.3, or in no headache group, 304.3 ± 137.4 (p = 0.02 and p < 0.001, respectively). Conclusion: Back pain is highly frequent in individuals with CH, followed by EH and no headache. In persons with CH, back pain is associated with lower cephalic and extracephalic PPTs suggesting central sensitization may be a substrate or consequence of comorbidity. Significance: We found that back pain has high relative frequency in individuals with CH followed EH and no headache. Back pain is associated with low cephalic and extracephalic PPTs in individuals with CH. Central sensitization may be a substrate or consequence of this comorbidity of back pain and CH.
AB - Background: Low back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self-reported back pain in persons with and without primary headaches and examined pain sensitivity. Method: A population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self-administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (<15 headache days/month) (EH). A total of 495 had a pericranial total tenderness score (TTS), and 494 had cephalic and extracephalic pressure pain thresholds (PPTs) assessed. Results: Adjusted for age, gender, education and poor self-rated health, 1-year relative frequency of back pain was higher in individuals with CH (82.5%) and EH (80.1%) compared to no headache group (65.7%). In persons with back pain, TTS was higher in CH, (26.3 ± 12.1) than in EH, (18.5 ± 10.0; p < 0.001) and higher in both groups than in those with no headache, 10.8 ± 8.5 (p < 0.001 and p < 0.001, respectively). In persons with back pain, temporalis PPT were lower in CH, 169.3 ± 57.8, than in EH, 225.2 ± 98.1, and in no headache group, 244.3 ± 105.4 (p = 0.02 and p = 0.01, respectively). In persons with back pain, finger PPT were lower in CH, 237.1 ± 106.7, than in EH, 291.3 ± 141.3, or in no headache group, 304.3 ± 137.4 (p = 0.02 and p < 0.001, respectively). Conclusion: Back pain is highly frequent in individuals with CH, followed by EH and no headache. In persons with CH, back pain is associated with lower cephalic and extracephalic PPTs suggesting central sensitization may be a substrate or consequence of comorbidity. Significance: We found that back pain has high relative frequency in individuals with CH followed EH and no headache. Back pain is associated with low cephalic and extracephalic PPTs in individuals with CH. Central sensitization may be a substrate or consequence of this comorbidity of back pain and CH.
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U2 - 10.1002/ejp.1176
DO - 10.1002/ejp.1176
M3 - Article
C2 - 29349847
AN - SCOPUS:85044451671
SN - 1090-3801
VL - 22
SP - 904
EP - 914
JO - European Journal of Pain
JF - European Journal of Pain
IS - 5
ER -