Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection

T. Ulrichs, P. Anding, S. Porcelli, S. H.E. Kaufmann, M. E. Munk

Research output: Contribution to journalArticle

66 Scopus citations


Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.

Original languageEnglish (US)
Pages (from-to)6073-6076
Number of pages4
JournalInfection and immunity
Issue number10
StatePublished - Jan 1 2000


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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