Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection

T. Ulrichs, P. Anding, Steven A. Porcelli, S. H E Kaufmann, M. E. Munk

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.

Original languageEnglish (US)
Pages (from-to)6073-6076
Number of pages4
JournalInfection and Immunity
Volume68
Issue number10
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Interferon-gamma
Tuberculosis
Mycobacterium bovis
Infection
Proteins
Interferons
Tissue Donors
Antigens
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection. / Ulrichs, T.; Anding, P.; Porcelli, Steven A.; Kaufmann, S. H E; Munk, M. E.

In: Infection and Immunity, Vol. 68, No. 10, 2000, p. 6073-6076.

Research output: Contribution to journalArticle

@article{8d2dc4602fe34bea9a241e0ebbe289f6,
title = "Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection",
abstract = "Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.",
author = "T. Ulrichs and P. Anding and Porcelli, {Steven A.} and Kaufmann, {S. H E} and Munk, {M. E.}",
year = "2000",
doi = "10.1128/IAI.68.10.6073-6076.2000",
language = "English (US)",
volume = "68",
pages = "6073--6076",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "10",

}

TY - JOUR

T1 - Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection

AU - Ulrichs, T.

AU - Anding, P.

AU - Porcelli, Steven A.

AU - Kaufmann, S. H E

AU - Munk, M. E.

PY - 2000

Y1 - 2000

N2 - Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.

AB - Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0033806210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033806210&partnerID=8YFLogxK

U2 - 10.1128/IAI.68.10.6073-6076.2000

DO - 10.1128/IAI.68.10.6073-6076.2000

M3 - Article

C2 - 10992526

AN - SCOPUS:0033806210

VL - 68

SP - 6073

EP - 6076

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 10

ER -