Abstract
Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6073-6076 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 68 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection. / Ulrichs, T.; Anding, P.; Porcelli, Steven A.; Kaufmann, S. H E; Munk, M. E.
In: Infection and Immunity, Vol. 68, No. 10, 2000, p. 6073-6076.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased numbers of ESAT-6- and purified protein derivative-specific gamma interferon-producing cells in subclinical and active tuberculosis infection
AU - Ulrichs, T.
AU - Anding, P.
AU - Porcelli, Steven A.
AU - Kaufmann, S. H E
AU - Munk, M. E.
PY - 2000
Y1 - 2000
N2 - Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.
AB - Numbers of gamma interferon (IFN-γ)-producing cells reactive to ESAT-6 antigen were increased in recent converters to purified protein derivative positivity and in tuberculosis patients but not in unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-γ-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus, ESAT-6 is a potential candidate for use in detection of early, as well as active, tuberculosis and for control of the disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033806210&partnerID=8YFLogxK
U2 - 10.1128/IAI.68.10.6073-6076.2000
DO - 10.1128/IAI.68.10.6073-6076.2000
M3 - Article
VL - 68
SP - 6073
EP - 6076
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 10
ER -