Increased lipid oxidation but normal muscle glycogen response to epinephrine in humans with IDDM

Neil Cohen, Meyer Halberstam, Luciano Rossetti, Harry Shamoon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of physiological increments in epinephrine and insulin on glucose production (GP), skeletal muscle glycogen metabolism, and substrate oxidation were studied in eight insulin-dependent diabetes mellitus (IDDM) and nine control subjects. Epinephrine was coinfused for the final 120 min of a 240-min euglycemic, hyperinsulinemic clamp. In both groups, insulin increased glucose uptake, glycogen synthesis, and whole body carbohydrate (CHO) oxidation and inhibited GP (by 70-80%) and lipid oxidation (by ~50%), whereas epinephrine antagonized the effect of insulin on glucose uptake and glycogen synthesis. In contrast, GP increased in IDDM subjects (P < 0.02) but remained suppressed by insulin in controls. CHO oxidation felt (1.37 ± 0.25 vs. 2.08 ± 0.32 mg · kg-1 · min-1) and lipid oxidation increased to baseline in IDDM subjects, with increments in plasma free fatty acids (FFA) and glycerol. In contrast, in controls, plasma FFA and glycerol remained suppressed and lipid oxidation decreased further with epinephrine (P < 0.005). Epinephrine completely reversed insulin's activation of muscle glycogen synthase in both groups. Thus, during hyperinsulinemia, the hepatic response to epinephrine in IDDM subjects may be dependent on activation of lipid oxidation. Skeletal muscle glycogen metabolism is exquisitely sensitive to epinephrine despite the presence of hyperinsulinemia.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume271
Issue number2 34-2
StatePublished - Aug 1996

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Medical problems
Glycogen
Type 1 Diabetes Mellitus
Epinephrine
Muscle
Insulin
Lipids
Muscles
Oxidation
Glucose
Hyperinsulinism
Nonesterified Fatty Acids
Glycerol
Metabolism
Skeletal Muscle
Chemical activation
Glycogen Synthase
Glucose Clamp Technique
Plasmas
Clamping devices

Keywords

  • free fatty acids
  • glucose turnover
  • glycerol
  • glycogen synthase
  • glycolysis

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Increased lipid oxidation but normal muscle glycogen response to epinephrine in humans with IDDM. / Cohen, Neil; Halberstam, Meyer; Rossetti, Luciano; Shamoon, Harry.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 271, No. 2 34-2, 08.1996.

Research output: Contribution to journalArticle

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