Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke

A concern for development of atopy early in childhood

Su Gülsün Berrak, Eren Özek, Dilşad Cebeci, Fazilet Karakoç, Müjdat Başaran, Elif Daǧli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: In adults several reports indicate that eosinophil counts and serum IgE levels increase in tandem with the number of cigarettes smoked. Several conflicting results have also been reported regarding prenatal cigarette smoke exposure and its effects on fetal immunoglobulin levels. Thus we surveyed cord-blood cotinine, IgE concentrations and eosinophil counts in 142 neonates in relation to parental smoking during pregnancy. Methods: This study was performed at Marmara University Hospital between July 1995 and May 1996. Pregnant women were selected at random. Cord-blood was collected at delivery and maternal urine samples were collected within the first hour after delivery. Complete blood count and differential counts were measured in the cord-blood samples within the first hour after delivery. Serum was separated from the cord-blood within 2 hours of collection and the specimens were stored at -30°C until assay, for cotinine and IgE. Results: Maternal urinary cotinine/creatinine ratio (UCCR) was used as a biologic marker of passive smoke exposure. Maternal UCCR and cord-blood cotinine levels were significantly correlated, and both were highest in the active smokers and their infants. Cord-blood eosinophil counts rose in tandem with maternal UCCR. Cord-blood IgE levels were correlated with maternal UCCR only for nonatopic mothers. No relationship was found between cord-blood cotinine, IgE levels, and eosinophil counts. Conclusion: We conclude that, maternal smoking, whether active and/or passive, affects cord-blood eosinophil counts in women without atopy. The implication of these findings in the development of atopy later in life have yet to be identified.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalMarmara Medical Journal
Volume15
Issue number2
StatePublished - Apr 2002
Externally publishedYes

Fingerprint

Cotinine
Fetal Blood
Eosinophils
Smoke
Tobacco
Mothers
Immunoglobulin E
Creatinine
Tobacco Products
Smoking
Specimen Handling
Blood Cell Count
Serum
Immunoglobulins
Pregnant Women
Biomarkers
Urine
Newborn Infant
Pregnancy

Keywords

  • Atopy
  • Cord-blood
  • Cotinine
  • Eosinophil
  • IgE
  • Newborn
  • Smoking

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Berrak, S. G., Özek, E., Cebeci, D., Karakoç, F., Başaran, M., & Daǧli, E. (2002). Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke: A concern for development of atopy early in childhood. Marmara Medical Journal, 15(2), 86-91.

Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke : A concern for development of atopy early in childhood. / Berrak, Su Gülsün; Özek, Eren; Cebeci, Dilşad; Karakoç, Fazilet; Başaran, Müjdat; Daǧli, Elif.

In: Marmara Medical Journal, Vol. 15, No. 2, 04.2002, p. 86-91.

Research output: Contribution to journalArticle

Berrak, SG, Özek, E, Cebeci, D, Karakoç, F, Başaran, M & Daǧli, E 2002, 'Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke: A concern for development of atopy early in childhood', Marmara Medical Journal, vol. 15, no. 2, pp. 86-91.
Berrak, Su Gülsün ; Özek, Eren ; Cebeci, Dilşad ; Karakoç, Fazilet ; Başaran, Müjdat ; Daǧli, Elif. / Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke : A concern for development of atopy early in childhood. In: Marmara Medical Journal. 2002 ; Vol. 15, No. 2. pp. 86-91.
@article{533ed949d4784fd5bb92cdd062e64c83,
title = "Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke: A concern for development of atopy early in childhood",
abstract = "Objective: In adults several reports indicate that eosinophil counts and serum IgE levels increase in tandem with the number of cigarettes smoked. Several conflicting results have also been reported regarding prenatal cigarette smoke exposure and its effects on fetal immunoglobulin levels. Thus we surveyed cord-blood cotinine, IgE concentrations and eosinophil counts in 142 neonates in relation to parental smoking during pregnancy. Methods: This study was performed at Marmara University Hospital between July 1995 and May 1996. Pregnant women were selected at random. Cord-blood was collected at delivery and maternal urine samples were collected within the first hour after delivery. Complete blood count and differential counts were measured in the cord-blood samples within the first hour after delivery. Serum was separated from the cord-blood within 2 hours of collection and the specimens were stored at -30°C until assay, for cotinine and IgE. Results: Maternal urinary cotinine/creatinine ratio (UCCR) was used as a biologic marker of passive smoke exposure. Maternal UCCR and cord-blood cotinine levels were significantly correlated, and both were highest in the active smokers and their infants. Cord-blood eosinophil counts rose in tandem with maternal UCCR. Cord-blood IgE levels were correlated with maternal UCCR only for nonatopic mothers. No relationship was found between cord-blood cotinine, IgE levels, and eosinophil counts. Conclusion: We conclude that, maternal smoking, whether active and/or passive, affects cord-blood eosinophil counts in women without atopy. The implication of these findings in the development of atopy later in life have yet to be identified.",
keywords = "Atopy, Cord-blood, Cotinine, Eosinophil, IgE, Newborn, Smoking",
author = "Berrak, {Su G{\"u}ls{\"u}n} and Eren {\"O}zek and Dilşad Cebeci and Fazilet Karako{\cc} and M{\"u}jdat Başaran and Elif Daǧli",
year = "2002",
month = "4",
language = "English (US)",
volume = "15",
pages = "86--91",
journal = "Marmara Medical Journal",
issn = "1019-1941",
publisher = "Marmara University",
number = "2",

}

TY - JOUR

T1 - Increased cord-blood eosinophil counts and prenatal exposure to tobacco smoke

T2 - A concern for development of atopy early in childhood

AU - Berrak, Su Gülsün

AU - Özek, Eren

AU - Cebeci, Dilşad

AU - Karakoç, Fazilet

AU - Başaran, Müjdat

AU - Daǧli, Elif

PY - 2002/4

Y1 - 2002/4

N2 - Objective: In adults several reports indicate that eosinophil counts and serum IgE levels increase in tandem with the number of cigarettes smoked. Several conflicting results have also been reported regarding prenatal cigarette smoke exposure and its effects on fetal immunoglobulin levels. Thus we surveyed cord-blood cotinine, IgE concentrations and eosinophil counts in 142 neonates in relation to parental smoking during pregnancy. Methods: This study was performed at Marmara University Hospital between July 1995 and May 1996. Pregnant women were selected at random. Cord-blood was collected at delivery and maternal urine samples were collected within the first hour after delivery. Complete blood count and differential counts were measured in the cord-blood samples within the first hour after delivery. Serum was separated from the cord-blood within 2 hours of collection and the specimens were stored at -30°C until assay, for cotinine and IgE. Results: Maternal urinary cotinine/creatinine ratio (UCCR) was used as a biologic marker of passive smoke exposure. Maternal UCCR and cord-blood cotinine levels were significantly correlated, and both were highest in the active smokers and their infants. Cord-blood eosinophil counts rose in tandem with maternal UCCR. Cord-blood IgE levels were correlated with maternal UCCR only for nonatopic mothers. No relationship was found between cord-blood cotinine, IgE levels, and eosinophil counts. Conclusion: We conclude that, maternal smoking, whether active and/or passive, affects cord-blood eosinophil counts in women without atopy. The implication of these findings in the development of atopy later in life have yet to be identified.

AB - Objective: In adults several reports indicate that eosinophil counts and serum IgE levels increase in tandem with the number of cigarettes smoked. Several conflicting results have also been reported regarding prenatal cigarette smoke exposure and its effects on fetal immunoglobulin levels. Thus we surveyed cord-blood cotinine, IgE concentrations and eosinophil counts in 142 neonates in relation to parental smoking during pregnancy. Methods: This study was performed at Marmara University Hospital between July 1995 and May 1996. Pregnant women were selected at random. Cord-blood was collected at delivery and maternal urine samples were collected within the first hour after delivery. Complete blood count and differential counts were measured in the cord-blood samples within the first hour after delivery. Serum was separated from the cord-blood within 2 hours of collection and the specimens were stored at -30°C until assay, for cotinine and IgE. Results: Maternal urinary cotinine/creatinine ratio (UCCR) was used as a biologic marker of passive smoke exposure. Maternal UCCR and cord-blood cotinine levels were significantly correlated, and both were highest in the active smokers and their infants. Cord-blood eosinophil counts rose in tandem with maternal UCCR. Cord-blood IgE levels were correlated with maternal UCCR only for nonatopic mothers. No relationship was found between cord-blood cotinine, IgE levels, and eosinophil counts. Conclusion: We conclude that, maternal smoking, whether active and/or passive, affects cord-blood eosinophil counts in women without atopy. The implication of these findings in the development of atopy later in life have yet to be identified.

KW - Atopy

KW - Cord-blood

KW - Cotinine

KW - Eosinophil

KW - IgE

KW - Newborn

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0036556795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036556795&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 86

EP - 91

JO - Marmara Medical Journal

JF - Marmara Medical Journal

SN - 1019-1941

IS - 2

ER -