@article{5f075c700f60467bbf33cb7c09328816,
title = "Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates—AWAKEN]",
abstract = "Background: Hypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age. Methods: Diagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications. Undiagnosed hypertension was defined when infants did not have a diagnosis of hypertension, but >50% of the lowest mean, diastolic and systolic blood pressure recordings were >95th percentile for gestational age. Results: Of the 2162 neonates enrolled in the study, hypertension was documented in 1.8%. An additional 3.7% were defined as having undiagnosed hypertension. There was a significant correlation with neonatal hypertension and acute kidney injury (AKI). Additional risk factors for neonatal hypertension were hyperbilirubinaemia, Caucasian race, outborn, vaginal delivery, and congenital heart disease. Protective factors were small for gestational age, multiple gestations, and steroids for fetal maturation. Conclusions: Neonatal hypertension may be an under-recognized condition. AKI and other risk factors predispose infants to hypertension.",
author = "{On Behalf Of The Neonatal Kidney Collaborative (Nkc)} and Kraut, {Emily J.} and Boohaker, {Louis J.} and Askenazi, {David J.} and Jeffery Fletcher and Kent, {Alison L.} and Selewski, {David T.} and Subrata Sarkar and Alison Kent and Jeffery Fletcher and Abitbol, {Carolyn L.} and Marissa DeFreitas and Shahnaz Duara and Charlton, {Jennifer R.} and Ronnie Guillet and Carl D{\textquoteright}Angio and Ayesa Mian and Erin Rademacher and Mhanna, {Maroun J.} and Rupesh Raina and Deepak Kumar and Namasivayam Ambalavanan and Arikan, {Ayse Akcan} and Rhee, {Christopher J.} and Goldstein, {Stuart L.} and Nathan, {Amy T.} and Alok Bhutada and Shantanu Rastogi and Elizabeth Bonachea and Susan Ingraham and John Mahan and Arwa Nada and Brophy, {Patrick D.} and Colaizy, {Tarah T.} and Klein, {Jonathan M.} and Cole, {F. Sessions} and Davis, {T. Keefe} and Joshua Dower and Lawrence Milner and Alexandra Smith and Mamta Fuloria and Kimberly Reidy and Kaskel, {Frederick J.} and Jason Gien and Gist, {Katja M.} and Hanna, {Mina H.} and Sangeeta Hingorani and Michelle Starr and Catherine Joseph and Tara DuPont and Robin Ohls",
note = "Funding Information: Cincinnati Children{\textquoteright}s Hospital Center for Acute Care Nephrology provided funding to create and maintain the AWAKEN Medidata Rave electronic database. The Pediatric and Infant Center for Acute Nephrology (PICAN) provided support for web meetings for the NKC steering committee annual meeting at the University of Alabama at Birmingham (UAB), as well as support for some of the AWAKEN investigators at UAB (LBJ, RJG). PICAN is part of the Department of Pediatrics at the University of Alabama at Birmingham (UAB), and is funded by Children{\textquoteright}s of Alabama Hospital, the Department of Pediatrics, UAB School of Medicine, and UAB{\textquoteright}s Center for Clinical and Translational Sciences (CCTS, NIH grant UL1TR001417). Finally, the AWAKEN study at the University of New Mexico was supported by the Clinical and Translational Science Center (CTSC, NIH grant UL1TR001449) and by the University of Iowa Institute for Clinical and Translational Science (U54TR001356). Publisher Copyright: {\textcopyright} 2018, International Pediatric Research Foundation, Inc.",
year = "2018",
month = aug,
day = "1",
doi = "10.1038/s41390-018-0018-8",
language = "English (US)",
volume = "84",
pages = "279--289",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "2",
}