In vivo light scattering measurements for detection of precancerous conditions of the cervix

Judith R. Mourant, Thérese J. Bocklage, Tamara M. Powers, Heather M. Greene, Kathy L. Bullock, Lisa R. Marr-Lyon, Maxine H. Dorin, Alan G. Waxman, Meggan M. Zsemlye, Harriet O. Smith

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Objective.: To examine the utility of in vivo elastic light scattering measurements to diagnose high grade squamous interepithelial lesions (HSIL) of the cervix. Methods.: A newly developed fiber optic probe was used to measure light transport in the cervical epithelium of 36 patients undergoing standard colposcopy. Both unpolarized and polarized light transport were measured in the visible and near-infrared. Spectroscopic results of 29 patients were compared with histopathology of the measured sites using ROC curves, MANOVA and logistic regression. Results.: Three spectroscopic parameters are statistically different for HSIL compared with low-grade lesions and normal tissue. When these three spectroscopic parameters are combined, retrospective sensitivities and specificities for HSIL versus non-HSIL are 100% and 80%, respectively. Conclusions.: Reflectance measurements of elastically scattered light show promise as a non-invasive, real-time method to discriminate HSIL from other abnormalities and normal tissue. These results compare favorably with those obtained by fluorescence alone and by fluorescence combined with light scattering.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalGynecologic Oncology
Volume105
Issue number2
DOIs
StatePublished - May 1 2007

Keywords

  • Cervical cancer
  • Light scattering
  • Squamous intraepithelial lesions

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Mourant, J. R., Bocklage, T. J., Powers, T. M., Greene, H. M., Bullock, K. L., Marr-Lyon, L. R., Dorin, M. H., Waxman, A. G., Zsemlye, M. M., & Smith, H. O. (2007). In vivo light scattering measurements for detection of precancerous conditions of the cervix. Gynecologic Oncology, 105(2), 439-445. https://doi.org/10.1016/j.ygyno.2007.01.001