In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix

Judith R. Mourant, Tamara M. Powers, Thérese J. Bocklage, Heather M. Greene, Maxine H. Dorin, Alan G. Waxman, Meggan M. Zsemlye, Harriet O. Smith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A noninvasive optical diagnostic system for detection of cancerous and precancerous lesions of the cervix was evaluated in vivo. The optical system included a fiber-optic probe designed to measure polarized and unpolarized light transport properties of a small volume of tissue. An algorithm for diagnosing tissue based on the optical measurements was developed that used four optical properties, three of which were related to light scattering properties and the fourth of which was related to hemoglobin concentration. A sensitivity of -77% and specificities in the mid 60% range were obtained for separating high grade squamous intraepithelial lesions and cancer from other pathologies and normal tissue. The use of different cross-validation methods in algorithm development is analyzed, and the relative difficulties of diagnosing certain pathologies are assessed. Furthermore, the robustness of the optical system for use by different doctors and to changes in fiber-optic probe are also assessed, and potential improvements in the optical system are discussed.

Original languageEnglish (US)
JournalApplied Optics
Volume48
Issue number10
DOIs
StatePublished - Apr 1 2009

Fingerprint

Optical systems
Light scattering
lesions
light scattering
pathology
Pathology
Tissue
Fiber optics
fiber optics
probes
Hemoglobin
hemoglobin
optical measurement
Transport properties
polarized light
grade
Optical properties
transport properties
cancer
optical properties

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Mourant, J. R., Powers, T. M., Bocklage, T. J., Greene, H. M., Dorin, M. H., Waxman, A. G., ... Smith, H. O. (2009). In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix. Applied Optics, 48(10). https://doi.org/10.1364/AO.48.000D26

In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix. / Mourant, Judith R.; Powers, Tamara M.; Bocklage, Thérese J.; Greene, Heather M.; Dorin, Maxine H.; Waxman, Alan G.; Zsemlye, Meggan M.; Smith, Harriet O.

In: Applied Optics, Vol. 48, No. 10, 01.04.2009.

Research output: Contribution to journalArticle

Mourant, JR, Powers, TM, Bocklage, TJ, Greene, HM, Dorin, MH, Waxman, AG, Zsemlye, MM & Smith, HO 2009, 'In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix', Applied Optics, vol. 48, no. 10. https://doi.org/10.1364/AO.48.000D26
Mourant JR, Powers TM, Bocklage TJ, Greene HM, Dorin MH, Waxman AG et al. In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix. Applied Optics. 2009 Apr 1;48(10). https://doi.org/10.1364/AO.48.000D26
Mourant, Judith R. ; Powers, Tamara M. ; Bocklage, Thérese J. ; Greene, Heather M. ; Dorin, Maxine H. ; Waxman, Alan G. ; Zsemlye, Meggan M. ; Smith, Harriet O. / In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix. In: Applied Optics. 2009 ; Vol. 48, No. 10.
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