In vivo insulin action in hepatocellular and cholestatic liver cirrhosis

Nir Barzilai, P. Cohen, E. Karnieli, R. Enat, O. Epstein, J. Owen, N. McIntyre

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The in vivo dose response curve to insulin were studied, using an euglycemic insulin clamp technique, in 13 cirrhotic patients [8 with 'hepatocellular' (HC) (nonalcoholics) and 5 with 'cholestatic' (CHOL) cirrhosis] and 12 healthy controls (N). Subjects were studied in the basal state and during infusion of insulin at 3 different rates - 1, 3, 10 mU kg-1 min-1. Insulin responsiveness was similar in N and in HC, but it was 23% greater in CHOL (p < 0.001). Insulin sensitivity was decreased in cirrhotics as compared with N but this difference was only significant (p < 0.001) in HC. (ED50:62 + 5, 88 + 13 and 136 + 16 μU ml-1 in N, CHOL and HC respectively). Insulin clearance rate (ICR) was significantly (p < 0.005) decreased in HC (1060 ± 80, 996 ± 95 and 776 ± 128 ml sq m-1 ml-1 in N, CHOL and HC respectively. Basal hepatic glucose production (BHGP) was 39% lower in HC (p < 0.005) and 24% lower in CHOL (p < 0.05) than in N. Erythrocyte cholesterol phospholipid ratio was significantly elevated (p < 0.001) in both groups of cirrhotic patients but was not correlated to specific metabolic changes described. In summary: i) intervariations in insulin dependent glucose metabolism, were described in different cirrhotic groups; ii) basal hepatic glucose production and insulin clearance rate impaired in the different groups of cirrhotics; iii) the role of decreased cholesterol/phospholipid ratio on tissues glucose metabolism in cirrhotic patients should be further studied.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalJournal of Endocrinological Investigation
Volume14
Issue number9
StatePublished - 1991
Externally publishedYes

Fingerprint

Liver Cirrhosis
Insulin
Glucose
Phospholipids
Cholesterol
Glucose Clamp Technique
Liver
Insulin Resistance
Fibrosis
Erythrocytes

Keywords

  • Cholestatic cirrhosis
  • Glucose
  • Hepatocellular cirrhosis
  • Insulin
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology

Cite this

Barzilai, N., Cohen, P., Karnieli, E., Enat, R., Epstein, O., Owen, J., & McIntyre, N. (1991). In vivo insulin action in hepatocellular and cholestatic liver cirrhosis. Journal of Endocrinological Investigation, 14(9), 727-735.

In vivo insulin action in hepatocellular and cholestatic liver cirrhosis. / Barzilai, Nir; Cohen, P.; Karnieli, E.; Enat, R.; Epstein, O.; Owen, J.; McIntyre, N.

In: Journal of Endocrinological Investigation, Vol. 14, No. 9, 1991, p. 727-735.

Research output: Contribution to journalArticle

Barzilai, N, Cohen, P, Karnieli, E, Enat, R, Epstein, O, Owen, J & McIntyre, N 1991, 'In vivo insulin action in hepatocellular and cholestatic liver cirrhosis', Journal of Endocrinological Investigation, vol. 14, no. 9, pp. 727-735.
Barzilai, Nir ; Cohen, P. ; Karnieli, E. ; Enat, R. ; Epstein, O. ; Owen, J. ; McIntyre, N. / In vivo insulin action in hepatocellular and cholestatic liver cirrhosis. In: Journal of Endocrinological Investigation. 1991 ; Vol. 14, No. 9. pp. 727-735.
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AU - Cohen, P.

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AU - Owen, J.

AU - McIntyre, N.

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