In vivo imaging of dendritic pruning in dentate granule cells

J. Tiago Gonçalves, Cooper W. Bloyd, Matthew Shtrahman, Stephen T. Johnston, Simon T. Schafer, Sarah L. Parylak, Thanh Tran, Tina Chang, Fred H. Gage

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Original languageEnglish (US)
Pages (from-to)788-791
Number of pages4
JournalNature Neuroscience
Volume19
Issue number6
DOIs
StatePublished - Apr 26 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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    Gonçalves, J. T., Bloyd, C. W., Shtrahman, M., Johnston, S. T., Schafer, S. T., Parylak, S. L., Tran, T., Chang, T., & Gage, F. H. (2016). In vivo imaging of dendritic pruning in dentate granule cells. Nature Neuroscience, 19(6), 788-791. https://doi.org/10.1038/nn.4301