@article{6d100599162b4386be38de31a1b14ab8,
title = "In vivo imaging of dendritic pruning in dentate granule cells",
abstract = "We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.",
author = "Gon{\c c}alves, {J. Tiago} and Bloyd, {Cooper W.} and Matthew Shtrahman and Johnston, {Stephen T.} and Schafer, {Simon T.} and Parylak, {Sarah L.} and Thanh Tran and Tina Chang and Gage, {Fred H.}",
note = "Funding Information: We thank L. Moore, E. Mejia, S. Marshall and J. Arroyo for their technical help. We thank P.-C. Lee for his help with the 4D SPA software, C. O{\textquoteright}Donnell for his help with analysis, and M.L. Gage for editorial comments. This work was supported by grants from The James S. McDonnell Foundation (J.T.G., S.T.J., S.T.S. and F.H.G.), CIRM Grant TB1-01175 (C.W.B.), G. Harold & Leila Y. Mathers Charitable Foundation, Annette Merle-Smith, JPB Foundation, NIH Grants MH095741 and MH092758, The Leona M. and Harry B. Helmsley Charitable Trust Grant #2012-PG-MED00 (F.H.G.), Salk Innovation Grant (M.S.) and the Lewis Biophotonics Fellowship (S.T.J.). Publisher Copyright: {\textcopyright} 2016 Nature America, Inc. All rights reserved.",
year = "2016",
month = apr,
day = "26",
doi = "10.1038/nn.4301",
language = "English (US)",
volume = "19",
pages = "788--791",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "6",
}