In vivo imaging of dendritic pruning in dentate granule cells

J. Tiago Goncalves, Cooper W. Bloyd, Matthew Shtrahman, Stephen T. Johnston, Simon T. Schafer, Sarah L. Parylak, Thanh Tran, Tina Chang, Fred H. Gage

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Original languageEnglish (US)
JournalNature Neuroscience
DOIs
StateAccepted/In press - May 2 2016
Externally publishedYes

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Neuronal Plasticity
Dendrites
Growth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Goncalves, J. T., Bloyd, C. W., Shtrahman, M., Johnston, S. T., Schafer, S. T., Parylak, S. L., ... Gage, F. H. (Accepted/In press). In vivo imaging of dendritic pruning in dentate granule cells. Nature Neuroscience. https://doi.org/10.1038/nn.4301

In vivo imaging of dendritic pruning in dentate granule cells. / Goncalves, J. Tiago; Bloyd, Cooper W.; Shtrahman, Matthew; Johnston, Stephen T.; Schafer, Simon T.; Parylak, Sarah L.; Tran, Thanh; Chang, Tina; Gage, Fred H.

In: Nature Neuroscience, 02.05.2016.

Research output: Contribution to journalArticle

Goncalves, JT, Bloyd, CW, Shtrahman, M, Johnston, ST, Schafer, ST, Parylak, SL, Tran, T, Chang, T & Gage, FH 2016, 'In vivo imaging of dendritic pruning in dentate granule cells', Nature Neuroscience. https://doi.org/10.1038/nn.4301
Goncalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL et al. In vivo imaging of dendritic pruning in dentate granule cells. Nature Neuroscience. 2016 May 2. https://doi.org/10.1038/nn.4301
Goncalves, J. Tiago ; Bloyd, Cooper W. ; Shtrahman, Matthew ; Johnston, Stephen T. ; Schafer, Simon T. ; Parylak, Sarah L. ; Tran, Thanh ; Chang, Tina ; Gage, Fred H. / In vivo imaging of dendritic pruning in dentate granule cells. In: Nature Neuroscience. 2016.
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