In vivo imaging of dendritic pruning in dentate granule cells

J. Tiago Gonçalves; Cooper W. Bloyd; Matthew Shtrahman; Stephen T. Johnston; Simon T. Schafer; Sarah L. Parylak; Thanh Tran; Tina Chang; Fred H. Gage

doi:10.1038/nn.4301

In vivo imaging of dendritic pruning in dentate granule cells

J. Tiago Gonçalves, Cooper W. Bloyd, Matthew Shtrahman, Stephen T. Johnston, Simon T. Schafer, Sarah L. Parylak, Thanh Tran, Tina Chang, Fred H. Gage

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Original language	English (US)
Pages (from-to)	788-791
Number of pages	4
Journal	Nature Neuroscience
Volume	19
Issue number	6
DOIs	https://doi.org/10.1038/nn.4301
State	Published - Apr 26 2016
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "In vivo imaging of dendritic pruning in dentate granule cells",

abstract = "We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.",

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AU - Gonçalves, J. Tiago

AU - Bloyd, Cooper W.

AU - Shtrahman, Matthew

AU - Johnston, Stephen T.

AU - Schafer, Simon T.

AU - Parylak, Sarah L.

AU - Tran, Thanh

AU - Chang, Tina

AU - Gage, Fred H.

PY - 2016/4/26

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AB - We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

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In vivo imaging of dendritic pruning in dentate granule cells

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ASJC Scopus subject areas

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