In the right place at the right time

Visualizing and understanding mRNA localization

Adina R. Buxbaum, Gal Haimovich, Robert H. Singer

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

The spatial regulation of protein translation is an efficient way to create functional and structural asymmetries in cells. Recent research has furthered our understanding of how individual cells spatially organize protein synthesis, by applying innovative technology to characterize the relationship between mRNAs and their regulatory proteins, single-mRNA trafficking dynamics, physiological effects of abrogating mRNA localization in vivo and for endogenous mRNA labelling. The implementation of new imaging technologies has yielded valuable information on mRNA localization, for example, by observing single molecules in tissues. The emerging movements and localization patterns of mRNAs in morphologically distinct unicellular organisms and in neurons have illuminated shared and specialized mechanisms of mRNA localization, and this information is complemented by transgenic and biochemical techniques that reveal the biological consequences of mRNA mislocalization.

Original languageEnglish (US)
Pages (from-to)95-109
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume16
Issue number2
DOIs
StatePublished - Jan 15 2015

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Messenger RNA
Technology
Protein Biosynthesis
Proteins
Neurons
Research

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Medicine(all)

Cite this

In the right place at the right time : Visualizing and understanding mRNA localization. / Buxbaum, Adina R.; Haimovich, Gal; Singer, Robert H.

In: Nature Reviews Molecular Cell Biology, Vol. 16, No. 2, 15.01.2015, p. 95-109.

Research output: Contribution to journalArticle

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