In situ vaccination: Cancer immunotherapy both personalized and off-the-shelf

Linda Hammerich, Adam Binder, Joshua D. Brody

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

As cancer immunotherapy continues to benefit from novel approaches which cut immune 'brake pedals' (e.g. anti-PD1 and anti-CTLA4 antibodies) and push immune cell gas pedals (e.g. IL2, and IFNα) there will be increasing need to develop immune 'steering wheels' such as vaccines to guide the immune system specifically toward tumor associated antigens. Two primary hurdles in cancer vaccines have been: identification of universal antigens to be used in 'off-the-shelf' vaccines for common cancers, and 2) logistical hurdles of ex vivo production of individualized whole tumor cell vaccines. Here we summarize approaches using '. in situ vaccination' in which intratumoral administration of off-the-shelf immunomodulators have been developed to specifically induce (or amplify) T cell responses to each patient's individual tumor. Clinical studies have confirmed the induction of systemic immune and clinical responses to such approaches and preclinical models have suggested ways to further potentiate the translation of in situ vaccine trials for our patients.

Original languageEnglish (US)
Pages (from-to)1966-1981
Number of pages16
JournalMolecular Oncology
Volume9
Issue number10
DOIs
StatePublished - Dec 1 2015

Keywords

  • Cancer immunotherapy
  • Checkpoint blockade
  • Dendritic cells
  • In situ vaccination
  • Oncolytic viruses
  • Toll like receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

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