Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia

J. Melamed, Arye Rubinstein, A. Kadish, T. Manabe, M. Santorineou, A. Einhorn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A case of ectodermal dysplasia and aplastic anemia is presented in which a cell-mediated immunodeficiency led to a fatal pneumocystis carinii infection. Elevated levels of IgG, IgA and IgD were present with normal specific antibody titers. A deficient cell-mediated immunity was documented by low T cell numbers, poor in vitro mitogenic responses, negative skin tests and by the histologic finding at autopsy of thymic dysplasia.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalHelvetica Paediatrica Acta
Volume33
Issue number2
StatePublished - 1978

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Pneumocystis Infections
Ectodermal Dysplasia
Immunoglobulin D
Aplastic Anemia
Skin Tests
Cellular Immunity
Immunoglobulin A
Autopsy
Cell Count
Immunoglobulin G
T-Lymphocytes
Antibodies
In Vitro Techniques

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Melamed, J., Rubinstein, A., Kadish, A., Manabe, T., Santorineou, M., & Einhorn, A. (1978). Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia. Helvetica Paediatrica Acta, 33(2), 169-176.

Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia. / Melamed, J.; Rubinstein, Arye; Kadish, A.; Manabe, T.; Santorineou, M.; Einhorn, A.

In: Helvetica Paediatrica Acta, Vol. 33, No. 2, 1978, p. 169-176.

Research output: Contribution to journalArticle

Melamed, J, Rubinstein, A, Kadish, A, Manabe, T, Santorineou, M & Einhorn, A 1978, 'Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia', Helvetica Paediatrica Acta, vol. 33, no. 2, pp. 169-176.
Melamed, J. ; Rubinstein, Arye ; Kadish, A. ; Manabe, T. ; Santorineou, M. ; Einhorn, A. / Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia. In: Helvetica Paediatrica Acta. 1978 ; Vol. 33, No. 2. pp. 169-176.
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