Impairment of cell-mediated immunity in ectodermal dysplasia with aplastic anemia

J. Melamed, A. Rubinstein, A. Kadish, T. Manabe, M. Santorineou, A. Einhorn

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A case of ectodermal dysplasia and aplastic anemia is presented in which a cell-mediated immunodeficiency led to a fatal pneumocystis carinii infection. Elevated levels of IgG, IgA and IgD were present with normal specific antibody titers. A deficient cell-mediated immunity was documented by low T cell numbers, poor in vitro mitogenic responses, negative skin tests and by the histologic finding at autopsy of thymic dysplasia.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalHelvetica Paediatrica Acta
Volume33
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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