Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats

J. D. Salamone, P. M. Beart, J. E. Alpert, S. D. Iversen

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Rats were trained on a reinforced alternation paradigm using an elevated T-maze. After pre-surgical training subjects received either ibotenic acid (4 μg/0.4 μl) or vehicle (pH 7.4, 0.4 μl) bilaterally into the region of the nucleus basalis magnocellularis - an important source of neocortical acetylcholine projections. Acetylcholinesterase staining of sectioned brains revealed a loss of neocortical, but not hippocampal staining in lesioned animals. On the T-maze task, lesioned rats showed significantly impaired choice performance relative to controls. They also demonstrated significant side biases, the degree of which was correlated with choice performance deficit.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalBehavioural Brain Research
Volume13
Issue number1
DOIs
StatePublished - Jul 1984
Externally publishedYes

Keywords

  • Alzheimer's disease
  • acetylcholine
  • alternation
  • neocortex
  • nucleus basalis magnocellularis
  • rat
  • spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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