Impact of Recent Findings on Study Design of Future Autism Clinical Trials

Eric Hollander, Ann Phillips, Bryan H. King, Donald Guthrie, Michael G. Aman, Paul Law, Thomas Owley, Ricki Robinson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalCNS Spectrums
Volume9
Issue number1
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Autistic Disorder
Clinical Trials
Amantadine
Psychopharmacology
Secretin
Risperidone
Fluoxetine
National Institutes of Health (U.S.)
Valproic Acid
Internet
Cross-Over Studies
Patient Selection
Multicenter Studies
Research Design
Outcome Assessment (Health Care)
Pediatrics
Research

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Hollander, E., Phillips, A., King, B. H., Guthrie, D., Aman, M. G., Law, P., ... Robinson, R. (2004). Impact of Recent Findings on Study Design of Future Autism Clinical Trials. CNS Spectrums, 9(1), 49-56.

Impact of Recent Findings on Study Design of Future Autism Clinical Trials. / Hollander, Eric; Phillips, Ann; King, Bryan H.; Guthrie, Donald; Aman, Michael G.; Law, Paul; Owley, Thomas; Robinson, Ricki.

In: CNS Spectrums, Vol. 9, No. 1, 01.2004, p. 49-56.

Research output: Contribution to journalArticle

Hollander, E, Phillips, A, King, BH, Guthrie, D, Aman, MG, Law, P, Owley, T & Robinson, R 2004, 'Impact of Recent Findings on Study Design of Future Autism Clinical Trials', CNS Spectrums, vol. 9, no. 1, pp. 49-56.
Hollander E, Phillips A, King BH, Guthrie D, Aman MG, Law P et al. Impact of Recent Findings on Study Design of Future Autism Clinical Trials. CNS Spectrums. 2004 Jan;9(1):49-56.
Hollander, Eric ; Phillips, Ann ; King, Bryan H. ; Guthrie, Donald ; Aman, Michael G. ; Law, Paul ; Owley, Thomas ; Robinson, Ricki. / Impact of Recent Findings on Study Design of Future Autism Clinical Trials. In: CNS Spectrums. 2004 ; Vol. 9, No. 1. pp. 49-56.
@article{c0f9db82d6224ad083f77d5c14b1cdca,
title = "Impact of Recent Findings on Study Design of Future Autism Clinical Trials",
abstract = "There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.",
author = "Eric Hollander and Ann Phillips and King, {Bryan H.} and Donald Guthrie and Aman, {Michael G.} and Paul Law and Thomas Owley and Ricki Robinson",
year = "2004",
month = "1",
language = "English (US)",
volume = "9",
pages = "49--56",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "1",

}

TY - JOUR

T1 - Impact of Recent Findings on Study Design of Future Autism Clinical Trials

AU - Hollander, Eric

AU - Phillips, Ann

AU - King, Bryan H.

AU - Guthrie, Donald

AU - Aman, Michael G.

AU - Law, Paul

AU - Owley, Thomas

AU - Robinson, Ricki

PY - 2004/1

Y1 - 2004/1

N2 - There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.

AB - There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.

UR - http://www.scopus.com/inward/record.url?scp=1842505964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842505964&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 49

EP - 56

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 1

ER -