Abstract
There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.
Original language | English (US) |
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Pages (from-to) | 49-56 |
Number of pages | 8 |
Journal | CNS spectrums |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health