Impact of intraventricular hemorrhage upon intracerebral hematoma expansion

Michael Moussouttas, Rishi Malhotra, Luis Fernandez, Mitchell Maltenfort, Melissa Holowecki, Jennifer Delgado, Nadine Lawson, Neeraj Badjatia

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: The purpose of this study is to determine whether intraventricular hemorrhage (IVH) exerts a "decompressive" effect that limits intracerebral hemorrhage (ICH) enlargement. Methods: Retrospective review of patients with spontaneous supratentorial ICH diagnosed within 6 h of onset, who underwent follow-up head CT approximately 48 h later. Digital imaging analysis of CT scans was performed to compare hematoma volume changes between patients with and without IVH. Hemorrhage locations were classified as paraventricular (PV) or non-PV. Regression analyses were employed to identify predictors of IVH, hematoma expansion, and mortality. Results: Of the 70 patients included 57% developed IVH, 85% of which occurred before initial CT. 71% of PV hemorrhages developed IVH, all before initial CT, and 48% of non-PV hemorrhages developed IVH, 29% of which occurred after initial CT. IVH was associated with PV location (P = 0.04), and among IVH patients PV location was associated with early IVH (P = 0.003). Predictors of mortality included age (P = 0.037), initial hematoma volume (P < 0.04), absolute volume change (P = 0.01), and final hematoma volume (P < 0.001). Variables predicting IVH included PV location (P < 0.0001), larger initial hematoma volume (P = 0.002), and greater absolute volume increase (P = 0.01). Hematoma expansion was greatest for non-PV with IVH (P = 0.08), and graphic inspection suggested that ICH volume tended to decrease with PV location and increase with IVH. Final hematoma volume was associated with initial volume (P < 0.0001), non-PV location (P = 0.02), and IVH (P = 0.04). Conclusions: IVH was not associated with less hematoma volume expansion, and for non-PV hemorrhages IVH was linked to greater volume increase.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalNeurocritical Care
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Keywords

  • Decompression
  • Digital image analysis
  • Enlargement
  • Expansion
  • Hematoma
  • Intracerebral hemorrhage
  • Intraventricular hemorrhage
  • Mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Impact of intraventricular hemorrhage upon intracerebral hematoma expansion'. Together they form a unique fingerprint.

  • Cite this

    Moussouttas, M., Malhotra, R., Fernandez, L., Maltenfort, M., Holowecki, M., Delgado, J., Lawson, N., & Badjatia, N. (2011). Impact of intraventricular hemorrhage upon intracerebral hematoma expansion. Neurocritical Care, 14(1), 50-54. https://doi.org/10.1007/s12028-010-9452-0