Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women

Jerome Kerzerho, Elizabeth J. McIlvaine, Patricia Anthony, Wendy J. Mack, Chia Hao Wang, Toni Frederick, Eva Operskalski, Zhi Chen, Lena Al-Harthi, Alan Landay, Mary A. Young, Phyllis C. Tien, Michael Augenbraun, Howard Strickler, Omid Akbari, Elizabeth T. Golub, Gerald B. Sharp, Andrea Kovacs

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Hepatitis C virus (HCV) infection causes an alteration in T-cell maturation and activation in patients coinfected with human immunodeficiency virus (HIV). Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART). Design and Methods: This prospective study included 56 HIV monoinfected, 55 HIV/HCV coinfected without HCV viremia, 132 HIV/HCV coinfected with HCV viremia, and 61 HIV/HCV-uninfected women for whom plasma levels of IL-7 were determined by enzyme-linked immunosorbent assay at 1 or more follow-up visits before and after HAART. Cross-sectional analyses of the associations between plasma IL-7 levels and HCV infection, demographic, clinical, and immunologic characteristics were evaluated using univariate and multivariate linear regression models before and after HAART. Results: In multivariate models, IL-7 levels were significantly higher in coinfected HCV viremic women than in HIV monoinfected women (multiplicative effect 1.48; 95% confidence interval: 1.01 to 2.16; P 0.04) before HAART, but were similar between these two groups among women after HAART. In addition to HCV viremia, higher IL-7 levels were associated with older age (P 0.02), lower CD4 + T-cell count (P 0.0007), and higher natural killer T-cell count (P 0.02) in women before HAART. Among HAART-treated women, only lower CD4 + T-cell count was significantly associated with IL-7 level (P 0.006). Conclusions: Our data demonstrate that in HIV-infected women, circulating levels of IL-7 are strongly associated with CD4 + T-cell depletion both before and after HAART. Our data also demonstrate that HCV viremia increases circulating IL-7 levels before HAART but not after HAART in coinfected women. This suggests that the effect of HCV on lymphopenia is abrogated by HAART.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume71
Issue number2
DOIs
StatePublished - Feb 1 2016

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Interleukin-7
Highly Active Antiretroviral Therapy
Hepacivirus
HIV-1
HIV
Viremia
T-Lymphocytes
Virus Diseases
CD4 Lymphocyte Count
Linear Models
Lymphopenia
Natural Killer T-Cells
Coinfection
Homeostasis
Cell Count
Cross-Sectional Studies

Keywords

  • HAART
  • HIV and HCV coinfection
  • IL-7 level

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Kerzerho, J., McIlvaine, E. J., Anthony, P., Mack, W. J., Wang, C. H., Frederick, T., ... Kovacs, A. (2016). Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. Journal of Acquired Immune Deficiency Syndromes, 71(2), 172-180. https://doi.org/10.1097/QAI.0000000000000832

Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. / Kerzerho, Jerome; McIlvaine, Elizabeth J.; Anthony, Patricia; Mack, Wendy J.; Wang, Chia Hao; Frederick, Toni; Operskalski, Eva; Chen, Zhi; Al-Harthi, Lena; Landay, Alan; Young, Mary A.; Tien, Phyllis C.; Augenbraun, Michael; Strickler, Howard; Akbari, Omid; Golub, Elizabeth T.; Sharp, Gerald B.; Kovacs, Andrea.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 71, No. 2, 01.02.2016, p. 172-180.

Research output: Contribution to journalArticle

Kerzerho, J, McIlvaine, EJ, Anthony, P, Mack, WJ, Wang, CH, Frederick, T, Operskalski, E, Chen, Z, Al-Harthi, L, Landay, A, Young, MA, Tien, PC, Augenbraun, M, Strickler, H, Akbari, O, Golub, ET, Sharp, GB & Kovacs, A 2016, 'Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women', Journal of Acquired Immune Deficiency Syndromes, vol. 71, no. 2, pp. 172-180. https://doi.org/10.1097/QAI.0000000000000832
Kerzerho, Jerome ; McIlvaine, Elizabeth J. ; Anthony, Patricia ; Mack, Wendy J. ; Wang, Chia Hao ; Frederick, Toni ; Operskalski, Eva ; Chen, Zhi ; Al-Harthi, Lena ; Landay, Alan ; Young, Mary A. ; Tien, Phyllis C. ; Augenbraun, Michael ; Strickler, Howard ; Akbari, Omid ; Golub, Elizabeth T. ; Sharp, Gerald B. ; Kovacs, Andrea. / Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. In: Journal of Acquired Immune Deficiency Syndromes. 2016 ; Vol. 71, No. 2. pp. 172-180.
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T1 - Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women

AU - Kerzerho, Jerome

AU - McIlvaine, Elizabeth J.

AU - Anthony, Patricia

AU - Mack, Wendy J.

AU - Wang, Chia Hao

AU - Frederick, Toni

AU - Operskalski, Eva

AU - Chen, Zhi

AU - Al-Harthi, Lena

AU - Landay, Alan

AU - Young, Mary A.

AU - Tien, Phyllis C.

AU - Augenbraun, Michael

AU - Strickler, Howard

AU - Akbari, Omid

AU - Golub, Elizabeth T.

AU - Sharp, Gerald B.

AU - Kovacs, Andrea

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N2 - Objectives: Hepatitis C virus (HCV) infection causes an alteration in T-cell maturation and activation in patients coinfected with human immunodeficiency virus (HIV). Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART). Design and Methods: This prospective study included 56 HIV monoinfected, 55 HIV/HCV coinfected without HCV viremia, 132 HIV/HCV coinfected with HCV viremia, and 61 HIV/HCV-uninfected women for whom plasma levels of IL-7 were determined by enzyme-linked immunosorbent assay at 1 or more follow-up visits before and after HAART. Cross-sectional analyses of the associations between plasma IL-7 levels and HCV infection, demographic, clinical, and immunologic characteristics were evaluated using univariate and multivariate linear regression models before and after HAART. Results: In multivariate models, IL-7 levels were significantly higher in coinfected HCV viremic women than in HIV monoinfected women (multiplicative effect 1.48; 95% confidence interval: 1.01 to 2.16; P 0.04) before HAART, but were similar between these two groups among women after HAART. In addition to HCV viremia, higher IL-7 levels were associated with older age (P 0.02), lower CD4 + T-cell count (P 0.0007), and higher natural killer T-cell count (P 0.02) in women before HAART. Among HAART-treated women, only lower CD4 + T-cell count was significantly associated with IL-7 level (P 0.006). Conclusions: Our data demonstrate that in HIV-infected women, circulating levels of IL-7 are strongly associated with CD4 + T-cell depletion both before and after HAART. Our data also demonstrate that HCV viremia increases circulating IL-7 levels before HAART but not after HAART in coinfected women. This suggests that the effect of HCV on lymphopenia is abrogated by HAART.

AB - Objectives: Hepatitis C virus (HCV) infection causes an alteration in T-cell maturation and activation in patients coinfected with human immunodeficiency virus (HIV). Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART). Design and Methods: This prospective study included 56 HIV monoinfected, 55 HIV/HCV coinfected without HCV viremia, 132 HIV/HCV coinfected with HCV viremia, and 61 HIV/HCV-uninfected women for whom plasma levels of IL-7 were determined by enzyme-linked immunosorbent assay at 1 or more follow-up visits before and after HAART. Cross-sectional analyses of the associations between plasma IL-7 levels and HCV infection, demographic, clinical, and immunologic characteristics were evaluated using univariate and multivariate linear regression models before and after HAART. Results: In multivariate models, IL-7 levels were significantly higher in coinfected HCV viremic women than in HIV monoinfected women (multiplicative effect 1.48; 95% confidence interval: 1.01 to 2.16; P 0.04) before HAART, but were similar between these two groups among women after HAART. In addition to HCV viremia, higher IL-7 levels were associated with older age (P 0.02), lower CD4 + T-cell count (P 0.0007), and higher natural killer T-cell count (P 0.02) in women before HAART. Among HAART-treated women, only lower CD4 + T-cell count was significantly associated with IL-7 level (P 0.006). Conclusions: Our data demonstrate that in HIV-infected women, circulating levels of IL-7 are strongly associated with CD4 + T-cell depletion both before and after HAART. Our data also demonstrate that HCV viremia increases circulating IL-7 levels before HAART but not after HAART in coinfected women. This suggests that the effect of HCV on lymphopenia is abrogated by HAART.

KW - HAART

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