TY - JOUR
T1 - Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women
AU - Kerzerho, Jerome
AU - McIlvaine, Elizabeth J.
AU - Anthony, Patricia
AU - Mack, Wendy J.
AU - Wang, Chia Hao
AU - Frederick, Toni
AU - Operskalski, Eva
AU - Chen, Zhi
AU - Al-Harthi, Lena
AU - Landay, Alan
AU - Young, Mary A.
AU - Tien, Phyllis C.
AU - Augenbraun, Michael
AU - Strickler, Howard D.
AU - Akbari, Omid
AU - Golub, Elizabeth T.
AU - Sharp, Gerald B.
AU - Kovacs, Andrea
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objectives: Hepatitis C virus (HCV) infection causes an alteration in T-cell maturation and activation in patients coinfected with human immunodeficiency virus (HIV). Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART). Design and Methods: This prospective study included 56 HIV monoinfected, 55 HIV/HCV coinfected without HCV viremia, 132 HIV/HCV coinfected with HCV viremia, and 61 HIV/HCV-uninfected women for whom plasma levels of IL-7 were determined by enzyme-linked immunosorbent assay at 1 or more follow-up visits before and after HAART. Cross-sectional analyses of the associations between plasma IL-7 levels and HCV infection, demographic, clinical, and immunologic characteristics were evaluated using univariate and multivariate linear regression models before and after HAART. Results: In multivariate models, IL-7 levels were significantly higher in coinfected HCV viremic women than in HIV monoinfected women (multiplicative effect 1.48; 95% confidence interval: 1.01 to 2.16; P 0.04) before HAART, but were similar between these two groups among women after HAART. In addition to HCV viremia, higher IL-7 levels were associated with older age (P 0.02), lower CD4 + T-cell count (P 0.0007), and higher natural killer T-cell count (P 0.02) in women before HAART. Among HAART-treated women, only lower CD4 + T-cell count was significantly associated with IL-7 level (P 0.006). Conclusions: Our data demonstrate that in HIV-infected women, circulating levels of IL-7 are strongly associated with CD4 + T-cell depletion both before and after HAART. Our data also demonstrate that HCV viremia increases circulating IL-7 levels before HAART but not after HAART in coinfected women. This suggests that the effect of HCV on lymphopenia is abrogated by HAART.
AB - Objectives: Hepatitis C virus (HCV) infection causes an alteration in T-cell maturation and activation in patients coinfected with human immunodeficiency virus (HIV). Because interleukin 7 (IL-7) is a major cytokine controlling T-cell homeostasis, we analyzed the potential influence of HCV coinfection on circulating IL-7 levels in HIV-infected women before and after highly active antiretroviral therapy (HAART). Design and Methods: This prospective study included 56 HIV monoinfected, 55 HIV/HCV coinfected without HCV viremia, 132 HIV/HCV coinfected with HCV viremia, and 61 HIV/HCV-uninfected women for whom plasma levels of IL-7 were determined by enzyme-linked immunosorbent assay at 1 or more follow-up visits before and after HAART. Cross-sectional analyses of the associations between plasma IL-7 levels and HCV infection, demographic, clinical, and immunologic characteristics were evaluated using univariate and multivariate linear regression models before and after HAART. Results: In multivariate models, IL-7 levels were significantly higher in coinfected HCV viremic women than in HIV monoinfected women (multiplicative effect 1.48; 95% confidence interval: 1.01 to 2.16; P 0.04) before HAART, but were similar between these two groups among women after HAART. In addition to HCV viremia, higher IL-7 levels were associated with older age (P 0.02), lower CD4 + T-cell count (P 0.0007), and higher natural killer T-cell count (P 0.02) in women before HAART. Among HAART-treated women, only lower CD4 + T-cell count was significantly associated with IL-7 level (P 0.006). Conclusions: Our data demonstrate that in HIV-infected women, circulating levels of IL-7 are strongly associated with CD4 + T-cell depletion both before and after HAART. Our data also demonstrate that HCV viremia increases circulating IL-7 levels before HAART but not after HAART in coinfected women. This suggests that the effect of HCV on lymphopenia is abrogated by HAART.
KW - HAART
KW - HIV and HCV coinfection
KW - IL-7 level
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U2 - 10.1097/QAI.0000000000000832
DO - 10.1097/QAI.0000000000000832
M3 - Article
C2 - 26761519
AN - SCOPUS:84955575585
SN - 1525-4135
VL - 71
SP - 172
EP - 180
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -
