Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm

Jorge Moscat, Ana Maria Cuervo, Maria T. Diaz-Meco

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

The mechanisms controlling immunosurveillance and immunoevasion often operate simultaneously to the triggering of the oncogenic signaling that results in tumor initiation. The resolution of the balance between anti-cancer immune responses and pro-tumorigenic pathways determines if a tumor cell survives and can remodel the microenvironment to reinforce immunosuppression or is eliminated by the immune system. Cancer cells must endure a toxic and metabolically challenging milieu. In its various forms, autophagy provides a way for transformed cells to survive by promoting catabolism and detoxification. Mounting evidence suggests that the boundaries between cancer immunity and mitogenic and metabolic programs are diffuse, with the same molecules likely serving several diverse roles in immunity and metabolism during tumor initiation and progression. Our recent data provide mechanistic detail and functional relevance of a new paradigm whereby the same signaling elements control immunity and autophagy in cancer.

Original languageEnglish (US)
Pages (from-to)226-227
Number of pages2
JournalAutophagy
Volume18
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Atypical PKC
  • ULK2
  • autophagy
  • immunosurveillance
  • interferon

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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