Immunophenotypic Markers and Antiretroviral Therapy (IMART): T cell activation and maturation help predict treatment response

Donna Mildvan, Ronald J. Bosch, Ryung S. Kim, John Spritzler, David W. Haas, Daniel Kuritzkes, Jonathan Kagan, Mostafa Nokta, Victor DeGruttola, Melanie Moreno, Alan Landay

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

To determine whether markers of T cell activation and maturation are independently predictive of the response to potent antiretroviral therapy, the Immunophenotypic Markers and Antiretroviral Therapy study applied a novel data-sharing strategy across 5 Adult AIDS Clinical Trial Group trials that counted naive and activated CD4+ and CD8+ T cells in 324 subjects. Regression models - adjustment for baseline CD4 cell count, human immunodeficiency virus (HIV) RNA, and study - revealed that high pretreatment CD8+ T cell activation predicted virologic failure (P = .046). Additional models showed the greatest increase in CD4+ T cell counts in subjects with highest pretreatment naive CD4+ T cell counts (P<.0001), which was enhanced by high CD4+ and low CD8+ T cell activation. Total lymphocyte count also predicted a subsequent CD4 + T cell change. These results document the utility of T cell markers in predicting treatment outcome and their potential value for the study and management of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)1811-1820
Number of pages10
JournalJournal of Infectious Diseases
Volume189
Issue number10
DOIs
StatePublished - May 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Mildvan, D., Bosch, R. J., Kim, R. S., Spritzler, J., Haas, D. W., Kuritzkes, D., Kagan, J., Nokta, M., DeGruttola, V., Moreno, M., & Landay, A. (2004). Immunophenotypic Markers and Antiretroviral Therapy (IMART): T cell activation and maturation help predict treatment response. Journal of Infectious Diseases, 189(10), 1811-1820. https://doi.org/10.1086/383277