Immunological options for the treatment of tuberculosis: Evaluation of novel therapeutic approaches

Jacqueline M. Achkar, Arturo Casadevall, Aharona Glatman-Freedman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view of the epidemiological and clinical challenges, and explore the experience with immune-based therapies for the treatment of active tuberculosis. These immune-based therapies are discussed here with the aim of assessing their potential use as adjuncts to chemotherapy.

Original languageEnglish (US)
Pages (from-to)461-474
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Volume5
Issue number3
DOIs
StatePublished - Jun 2007

Fingerprint

Tuberculosis
Multidrug-Resistant Tuberculosis
Therapeutics
Allergy and Immunology
Coinfection
Mycobacterium tuberculosis
HIV
Drug Therapy

Keywords

  • Antibodies
  • Cytokines
  • Immunotherapy
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Immunological options for the treatment of tuberculosis : Evaluation of novel therapeutic approaches. / Achkar, Jacqueline M.; Casadevall, Arturo; Glatman-Freedman, Aharona.

In: Expert Review of Anti-Infective Therapy, Vol. 5, No. 3, 06.2007, p. 461-474.

Research output: Contribution to journalArticle

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