Immunohistochemical evidence for the selective involvement of dorsal root fibres in Friedreich's ataxia

S. Goto, A. Hirano

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An immunohistochemical study was carried out in order to elucidate the selective involvement of the dorsal root fibres from two patients with Friedreich's ataxia in comparison with those of 10 neurologically normal control individuals. For this purpose, antibodies to substance P and to synaptophysin were used. Substance P-immunoreactive unmyelinated fibres forming a dense network in the normal substantia gelatinosa of the spinal dorsal horn predominantly originate from a subpopulation of small cells of the dorsal root ganglia, while synaptophysin is present in virtually all nerve cell axon terminals and is useful for visualizing axon terminals in the nervous system. Strong substance P-like immunoreactivity was seen in the substantia gelatinosa of patients with Friedreich's ataxia. By contrast, there was marked depletion of synaptophysin immunoreactivity in the posterior column nuclei, with the gracile nucleus showing greater loss of positive puncta than the cuneate nucleus.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalNeuropathology and Applied Neurobiology
Volume16
Issue number4
StatePublished - 1990

Fingerprint

Friedreich Ataxia
Synaptophysin
Spinal Nerve Roots
Substance P
Substantia Gelatinosa
Presynaptic Terminals
Spinal Ganglia
Nervous System
Neurons
Antibodies

Keywords

  • dorsal column nuclei
  • Friedreich's ataxia
  • substance P
  • substantia gelatinosa
  • synaptophysin

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Immunohistochemical evidence for the selective involvement of dorsal root fibres in Friedreich's ataxia. / Goto, S.; Hirano, A.

In: Neuropathology and Applied Neurobiology, Vol. 16, No. 4, 1990, p. 365-370.

Research output: Contribution to journalArticle

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