Abstract
An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3 ± 0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P < 0.01), and were mostly negative in prolactinomas and ACTHomas. In multivariate analysis, the proportions showed positive correlation with age (P < 0.01) and the Ki-67 (MIB-1) labeling index (P < 0.01) and tended to increase in number with recurrence (P < 0.05). In GHomas, these cells were more common in cases with low basal GH level (P < 0.01) and large tumor volume (P < 0.01). We consider that these cells represent oncocytes existing in varying numbers in adenomas. We suggest that oncocytic change in nongonadotrophic adenomas indicates poor differentiation and/or some aggressiveness, which lead to a decrease in the endocrine activity of the tumor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 428-433 |
| Number of pages | 6 |
| Journal | Virchows Archiv |
| Volume | 435 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Growth hormone-producing adenomas
- Immunohistochemistry
- Mitochondria
- Oncocytes
- Pituitary adenomas
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Immunohistochemical demonstration of oncocytes in nongonadotrophic pituitary adenomas. / Nishioka, Hiroshi; Ito, Hiroshi; Hirano, Asao.
In: Virchows Archiv, Vol. 435, No. 4, 1999, p. 428-433.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical demonstration of oncocytes in nongonadotrophic pituitary adenomas
AU - Nishioka, Hiroshi
AU - Ito, Hiroshi
AU - Hirano, Asao
PY - 1999
Y1 - 1999
N2 - An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3 ± 0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P < 0.01), and were mostly negative in prolactinomas and ACTHomas. In multivariate analysis, the proportions showed positive correlation with age (P < 0.01) and the Ki-67 (MIB-1) labeling index (P < 0.01) and tended to increase in number with recurrence (P < 0.05). In GHomas, these cells were more common in cases with low basal GH level (P < 0.01) and large tumor volume (P < 0.01). We consider that these cells represent oncocytes existing in varying numbers in adenomas. We suggest that oncocytic change in nongonadotrophic adenomas indicates poor differentiation and/or some aggressiveness, which lead to a decrease in the endocrine activity of the tumor.
AB - An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3 ± 0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P < 0.01), and were mostly negative in prolactinomas and ACTHomas. In multivariate analysis, the proportions showed positive correlation with age (P < 0.01) and the Ki-67 (MIB-1) labeling index (P < 0.01) and tended to increase in number with recurrence (P < 0.05). In GHomas, these cells were more common in cases with low basal GH level (P < 0.01) and large tumor volume (P < 0.01). We consider that these cells represent oncocytes existing in varying numbers in adenomas. We suggest that oncocytic change in nongonadotrophic adenomas indicates poor differentiation and/or some aggressiveness, which lead to a decrease in the endocrine activity of the tumor.
KW - Growth hormone-producing adenomas
KW - Immunohistochemistry
KW - Mitochondria
KW - Oncocytes
KW - Pituitary adenomas
UR - http://www.scopus.com/inward/record.url?scp=0032849411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032849411&partnerID=8YFLogxK
U2 - 10.1007/s004280050421
DO - 10.1007/s004280050421
M3 - Article
C2 - 10526007
AN - SCOPUS:0032849411
VL - 435
SP - 428
EP - 433
JO - Virchows Archiv
JF - Virchows Archiv
SN - 0945-6317
IS - 4
ER -