TY - JOUR
T1 - Immunohistochemical demonstration of oncocytes in nongonadotrophic pituitary adenomas
AU - Nishioka, Hiroshi
AU - Ito, Hiroshi
AU - Hirano, Asao
N1 - Funding Information:
Acknowledgements This study was supported in part by the Grant-in-Aid for Encouragement of Young Scientists (10770696) from the Japanese Ministry of Education, Science and Culture. The authors are indebted to Prof. J. Patrick Barron of the International Medical Communications Center of Tokyo Medical University for reviewing of this manuscript.
PY - 1999
Y1 - 1999
N2 - An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3 ± 0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P < 0.01), and were mostly negative in prolactinomas and ACTHomas. In multivariate analysis, the proportions showed positive correlation with age (P < 0.01) and the Ki-67 (MIB-1) labeling index (P < 0.01) and tended to increase in number with recurrence (P < 0.05). In GHomas, these cells were more common in cases with low basal GH level (P < 0.01) and large tumor volume (P < 0.01). We consider that these cells represent oncocytes existing in varying numbers in adenomas. We suggest that oncocytic change in nongonadotrophic adenomas indicates poor differentiation and/or some aggressiveness, which lead to a decrease in the endocrine activity of the tumor.
AB - An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3 ± 0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P < 0.01), and were mostly negative in prolactinomas and ACTHomas. In multivariate analysis, the proportions showed positive correlation with age (P < 0.01) and the Ki-67 (MIB-1) labeling index (P < 0.01) and tended to increase in number with recurrence (P < 0.05). In GHomas, these cells were more common in cases with low basal GH level (P < 0.01) and large tumor volume (P < 0.01). We consider that these cells represent oncocytes existing in varying numbers in adenomas. We suggest that oncocytic change in nongonadotrophic adenomas indicates poor differentiation and/or some aggressiveness, which lead to a decrease in the endocrine activity of the tumor.
KW - Growth hormone-producing adenomas
KW - Immunohistochemistry
KW - Mitochondria
KW - Oncocytes
KW - Pituitary adenomas
UR - http://www.scopus.com/inward/record.url?scp=0032849411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032849411&partnerID=8YFLogxK
U2 - 10.1007/s004280050421
DO - 10.1007/s004280050421
M3 - Article
C2 - 10526007
AN - SCOPUS:0032849411
VL - 435
SP - 428
EP - 433
JO - Virchows Archiv - Abteilung A Pathologische Anatomie
JF - Virchows Archiv - Abteilung A Pathologische Anatomie
SN - 0945-6317
IS - 4
ER -