Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma

Pallaiah Thammana, Matthew D. Scharff

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A subclone of an IgM‐producing hybridoma has been identified which has switched to producing an IgG1 antibody. The parent hybridoma, PC‐140, produces an antibody which binds phosphorylcholine and reacts with monoclonal antibodies that recognize myelomas of the T‐15 idiotype. The IgG1 antibody binds phosphorylcholine with the same affinity as the parental IgM and also reacts with the anti‐T‐15 monoclonal antibodies. While the IgM‐producing parent hybridoma does not express detectable surface IgM, the IgG1‐producing subclone produces both membrane and secreted IgG1.

Original languageEnglish (US)
Pages (from-to)614-619
Number of pages6
JournalEuropean Journal of Immunology
Issue number8
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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