Immune and Inflammatory Responses in the Central Nervous System: Modulation by Astrocytes

Milena Penkowa, Juan Hidalgo, Michael Aschner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.

Original languageEnglish (US)
JournalNeuroImmune Biology
Volume6
Issue numberC
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Astrocytes
Central Nervous System
Cytokines
Gliosis
Brain
Microglia
Automatic Data Processing
Names
Neurons

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Neurology

Cite this

Immune and Inflammatory Responses in the Central Nervous System : Modulation by Astrocytes. / Penkowa, Milena; Hidalgo, Juan; Aschner, Michael.

In: NeuroImmune Biology, Vol. 6, No. C, 2007.

Research output: Contribution to journalArticle

@article{22ed3894875f4a92a0a255882eb27a7d,
title = "Immune and Inflammatory Responses in the Central Nervous System: Modulation by Astrocytes",
abstract = "Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.",
author = "Milena Penkowa and Juan Hidalgo and Michael Aschner",
year = "2007",
doi = "10.1016/S1567-7443(07)10013-2",
language = "English (US)",
volume = "6",
journal = "NeuroImmune Biology",
issn = "1567-7443",
publisher = "Elsevier",
number = "C",

}

TY - JOUR

T1 - Immune and Inflammatory Responses in the Central Nervous System

T2 - Modulation by Astrocytes

AU - Penkowa, Milena

AU - Hidalgo, Juan

AU - Aschner, Michael

PY - 2007

Y1 - 2007

N2 - Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.

AB - Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.

UR - http://www.scopus.com/inward/record.url?scp=77957815986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957815986&partnerID=8YFLogxK

U2 - 10.1016/S1567-7443(07)10013-2

DO - 10.1016/S1567-7443(07)10013-2

M3 - Article

AN - SCOPUS:77957815986

VL - 6

JO - NeuroImmune Biology

JF - NeuroImmune Biology

SN - 1567-7443

IS - C

ER -