TY - JOUR
T1 - Immune and Inflammatory Responses in the Central Nervous System
T2 - Modulation by Astrocytes
AU - Penkowa, Milena
AU - Hidalgo, Juan
AU - Aschner, Michael
N1 - Funding Information:
This is review was supported in part by Public Health Service Grant NIEHS 07331 and 10563 (MA), the Ministerio de Ciencia y Tecnología and Feder (SAF2002-01268) and Direcció General de Recerca (2001SGR 00203) (JH).
PY - 2008
Y1 - 2008
N2 - Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.
AB - Beyond their long-recognized support functions, astrocytes are active partners of neurons in processing information, synaptic integration, and production of trophic factors, just to name a few. Both microglia and astrocytes produce and secrete a number of cytokines, modulating and integrating the communication between hematogenous cells and resident cells of the central nervous system (CNS). This review will address (1) the functions of astrocytes in the normal brain and (2) their role in surveying noxious stimuli within the brain, with particular emphasis on astrocytic responses to damage or disease, a process referred to as reactive astrogliosis/astrocytosis. In addition, the review will discuss (3) the role of astrocytes as an abundant cellular source for immunoregulatory (cytokines) factors, and their fundamental roles in the type and extent of CNS immune and inflammatory responses. (4) Recent experimental evidence on the role of astroglia in the etiology of neurological diseases will be highlighted, along with (5) the role of oxidative stressors generated within astrocytes in this process.
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U2 - 10.1016/S1567-7443(07)10013-2
DO - 10.1016/S1567-7443(07)10013-2
M3 - Review article
AN - SCOPUS:77957815986
SN - 1567-7443
VL - 6
SP - 275,277-288
JO - NeuroImmune Biology
JF - NeuroImmune Biology
IS - C
ER -