ILAE classification of the epilepsies

Position paper of the ILAE Commission for Classification and Terminology

Ingrid E. Scheffer, Samuel Berkovic, Giuseppe Capovilla, Mary B. Connolly, Jacqueline French, Laura Guilhoto, Edouard Hirsch, Satish Jain, Gary W. Mathern, Solomon L. Moshe, Douglas R. Nordli, Emilio Perucca, Torbjörn Tomson, Samuel Wiebe, Yue Hua Zhang, Sameer M. Zuberi

Research output: Contribution to journalArticle

549 Citations (Scopus)

Abstract

The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the major scientific advances that have taken place since the last ratified classification in 1989. As a critical tool for the practicing clinician, epilepsy classification must be relevant and dynamic to changes in thinking, yet robust and translatable to all areas of the globe. Its primary purpose is for diagnosis of patients, but it is also critical for epilepsy research, development of antiepileptic therapies, and communication around the world. The new classification originates from a draft document submitted for public comments in 2013, which was revised to incorporate extensive feedback from the international epilepsy community over several rounds of consultation. It presents three levels, starting with seizure type, where it assumes that the patient is having epileptic seizures as defined by the new 2017 ILAE Seizure Classification. After diagnosis of the seizure type, the next step is diagnosis of epilepsy type, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and also an unknown epilepsy group. The third level is that of epilepsy syndrome, where a specific syndromic diagnosis can be made. The new classification incorporates etiology along each stage, emphasizing the need to consider etiology at each step of diagnosis, as it often carries significant treatment implications. Etiology is broken into six subgroups, selected because of their potential therapeutic consequences. New terminology is introduced such as developmental and epileptic encephalopathy. The term benign is replaced by the terms self-limited and pharmacoresponsive, to be used where appropriate. It is hoped that this new framework will assist in improving epilepsy care and research in the 21st century.

Original languageEnglish (US)
Pages (from-to)512-521
Number of pages10
JournalEpilepsia
Volume58
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Terminology
Epilepsy
Generalized Epilepsy
Seizures
Partial Epilepsy
Brain Diseases
Research
Anticonvulsants
Therapeutics
Referral and Consultation
Communication

Keywords

  • Classification
  • Epilepsy syndromes
  • Etiology
  • Terminology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Scheffer, I. E., Berkovic, S., Capovilla, G., Connolly, M. B., French, J., Guilhoto, L., ... Zuberi, S. M. (2017). ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 58(4), 512-521. https://doi.org/10.1111/epi.13709

ILAE classification of the epilepsies : Position paper of the ILAE Commission for Classification and Terminology. / Scheffer, Ingrid E.; Berkovic, Samuel; Capovilla, Giuseppe; Connolly, Mary B.; French, Jacqueline; Guilhoto, Laura; Hirsch, Edouard; Jain, Satish; Mathern, Gary W.; Moshe, Solomon L.; Nordli, Douglas R.; Perucca, Emilio; Tomson, Torbjörn; Wiebe, Samuel; Zhang, Yue Hua; Zuberi, Sameer M.

In: Epilepsia, Vol. 58, No. 4, 01.04.2017, p. 512-521.

Research output: Contribution to journalArticle

Scheffer, IE, Berkovic, S, Capovilla, G, Connolly, MB, French, J, Guilhoto, L, Hirsch, E, Jain, S, Mathern, GW, Moshe, SL, Nordli, DR, Perucca, E, Tomson, T, Wiebe, S, Zhang, YH & Zuberi, SM 2017, 'ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology', Epilepsia, vol. 58, no. 4, pp. 512-521. https://doi.org/10.1111/epi.13709
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr 1;58(4):512-521. https://doi.org/10.1111/epi.13709
Scheffer, Ingrid E. ; Berkovic, Samuel ; Capovilla, Giuseppe ; Connolly, Mary B. ; French, Jacqueline ; Guilhoto, Laura ; Hirsch, Edouard ; Jain, Satish ; Mathern, Gary W. ; Moshe, Solomon L. ; Nordli, Douglas R. ; Perucca, Emilio ; Tomson, Torbjörn ; Wiebe, Samuel ; Zhang, Yue Hua ; Zuberi, Sameer M. / ILAE classification of the epilepsies : Position paper of the ILAE Commission for Classification and Terminology. In: Epilepsia. 2017 ; Vol. 58, No. 4. pp. 512-521.
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