IgM receptors on human lymphocytes: Detection by direct binding

J. A. Hardin; K. K. Nakaoka; J. M. Carboni

doi:10.1073/pnas.76.2.912

IgM receptors on human lymphocytes: Detection by direct binding

J. A. Hardin, K. K. Nakaoka, J. M. Carboni

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Abstract

Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10^-9 M^-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

Original language	English (US)
Pages (from-to)	912-914
Number of pages	3
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	76
Issue number	2
DOIs	https://doi.org/10.1073/pnas.76.2.912
State	Published - 1979
Externally published	Yes

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title = "IgM receptors on human lymphocytes: Detection by direct binding",

abstract = "Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10-9 M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.",

author = "Hardin, {J. A.} and Nakaoka, {K. K.} and Carboni, {J. M.}",

year = "1979",

doi = "10.1073/pnas.76.2.912",

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T1 - IgM receptors on human lymphocytes

T2 - Detection by direct binding

AU - Hardin, J. A.

AU - Nakaoka, K. K.

AU - Carboni, J. M.

PY - 1979

Y1 - 1979

N2 - Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10-9 M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

AB - Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10-9 M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

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JF - Proceedings of the National Academy of Sciences of the United States of America

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IgM receptors on human lymphocytes: Detection by direct binding

Abstract

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