IgM receptors on human lymphocytes: Detection by direct binding

J. A. Hardin, K. K. Nakaoka, J. M. Carboni

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10-9 M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

Original languageEnglish (US)
Pages (from-to)912-914
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number2
DOIs
StatePublished - 1979

ASJC Scopus subject areas

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