IgM receptors on human lymphocytes: Detection by direct binding

J. A. Hardin, K. K. Nakaoka, J. M. Carboni

Research output: Contribution to journalArticlepeer-review


Radioiodinated IgE isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent K(a) = 2.5 x 10-9 M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

Original languageEnglish (US)
Pages (from-to)912-914
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General


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