IFN-induced depression: a role for NSAIDs.

Gregory M. Asnis, Richard De la Garza, Shari R. Kohn, John F. Reinus, Margaret Henderson, Johar Shah

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Interferon-alpha (IFN) is widely used for the treatment of viral illnesses and other chronic diseases, though its usefulness is hampered by a problematic side-effect profile. In particular, IFN-alpha induces neuropsychiatric and neurotoxic side effects, including depression, anxiety, insomnia, lethargy, confusion, and psychosis. Of particular interest, a number of patients develop full psychiatric syndromes, particularly depressive disorders. Recent evidence suggests that conventional antidepressants (especially selective serotonin reuptake inhibitors) are effective in preventing or reducing IFN-induced side-effects, but even these compounds are not 100% effective in preventing these symptoms. As such, alternative treatments must be considered. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to counteract a number of IFN-induced side effects, including cytokine activation, stress hormone release, and neurochemical alterations (reduced 5-HT [serotonin]). NSAIDs are widely recommended for various aspects of flu-like symptoms or sickness behaviors in humans, including those induced specifically by IFN. In addition, NSAIDs appear to be effective in treating premenstrual dysphoric disorder. These data indirectly specify a role for NSAIDs in syndromes with a prominent depression component. Drawing from an extensive pre-clinical and clinical research base, we hypothesize that pretreatment with NSAIDs will not only reduce the incidence of flu-like symptoms, but also prove effective for the prevention or reduction of IFN-induced depression.

Original languageEnglish (US)
Pages (from-to)29-50
Number of pages22
JournalPsychopharmacology Bulletin
Volume37
Issue number3
StatePublished - Jun 2003

Fingerprint

Interferon-alpha
Anti-Inflammatory Agents
Depression
Pharmaceutical Preparations
Serotonin
Illness Behavior
Confusion
Lethargy
Serotonin Uptake Inhibitors
Sleep Initiation and Maintenance Disorders
Depressive Disorder
Psychotic Disorders
Antidepressive Agents
Psychiatry
Chronic Disease
Anxiety
Hormones
Cytokines
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Asnis, G. M., De la Garza, R., Kohn, S. R., Reinus, J. F., Henderson, M., & Shah, J. (2003). IFN-induced depression: a role for NSAIDs. Psychopharmacology Bulletin, 37(3), 29-50.

IFN-induced depression : a role for NSAIDs. / Asnis, Gregory M.; De la Garza, Richard; Kohn, Shari R.; Reinus, John F.; Henderson, Margaret; Shah, Johar.

In: Psychopharmacology Bulletin, Vol. 37, No. 3, 06.2003, p. 29-50.

Research output: Contribution to journalArticle

Asnis, GM, De la Garza, R, Kohn, SR, Reinus, JF, Henderson, M & Shah, J 2003, 'IFN-induced depression: a role for NSAIDs.', Psychopharmacology Bulletin, vol. 37, no. 3, pp. 29-50.
Asnis GM, De la Garza R, Kohn SR, Reinus JF, Henderson M, Shah J. IFN-induced depression: a role for NSAIDs. Psychopharmacology Bulletin. 2003 Jun;37(3):29-50.
Asnis, Gregory M. ; De la Garza, Richard ; Kohn, Shari R. ; Reinus, John F. ; Henderson, Margaret ; Shah, Johar. / IFN-induced depression : a role for NSAIDs. In: Psychopharmacology Bulletin. 2003 ; Vol. 37, No. 3. pp. 29-50.
@article{578d2939f1384f25a2d9d6bba5bc9f56,
title = "IFN-induced depression: a role for NSAIDs.",
abstract = "Interferon-alpha (IFN) is widely used for the treatment of viral illnesses and other chronic diseases, though its usefulness is hampered by a problematic side-effect profile. In particular, IFN-alpha induces neuropsychiatric and neurotoxic side effects, including depression, anxiety, insomnia, lethargy, confusion, and psychosis. Of particular interest, a number of patients develop full psychiatric syndromes, particularly depressive disorders. Recent evidence suggests that conventional antidepressants (especially selective serotonin reuptake inhibitors) are effective in preventing or reducing IFN-induced side-effects, but even these compounds are not 100{\%} effective in preventing these symptoms. As such, alternative treatments must be considered. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to counteract a number of IFN-induced side effects, including cytokine activation, stress hormone release, and neurochemical alterations (reduced 5-HT [serotonin]). NSAIDs are widely recommended for various aspects of flu-like symptoms or sickness behaviors in humans, including those induced specifically by IFN. In addition, NSAIDs appear to be effective in treating premenstrual dysphoric disorder. These data indirectly specify a role for NSAIDs in syndromes with a prominent depression component. Drawing from an extensive pre-clinical and clinical research base, we hypothesize that pretreatment with NSAIDs will not only reduce the incidence of flu-like symptoms, but also prove effective for the prevention or reduction of IFN-induced depression.",
author = "Asnis, {Gregory M.} and {De la Garza}, Richard and Kohn, {Shari R.} and Reinus, {John F.} and Margaret Henderson and Johar Shah",
year = "2003",
month = "6",
language = "English (US)",
volume = "37",
pages = "29--50",
journal = "Psychopharmacology Bulletin",
issn = "0048-5764",
publisher = "MedWorks Media LLC",
number = "3",

}

TY - JOUR

T1 - IFN-induced depression

T2 - a role for NSAIDs.

AU - Asnis, Gregory M.

AU - De la Garza, Richard

AU - Kohn, Shari R.

AU - Reinus, John F.

AU - Henderson, Margaret

AU - Shah, Johar

PY - 2003/6

Y1 - 2003/6

N2 - Interferon-alpha (IFN) is widely used for the treatment of viral illnesses and other chronic diseases, though its usefulness is hampered by a problematic side-effect profile. In particular, IFN-alpha induces neuropsychiatric and neurotoxic side effects, including depression, anxiety, insomnia, lethargy, confusion, and psychosis. Of particular interest, a number of patients develop full psychiatric syndromes, particularly depressive disorders. Recent evidence suggests that conventional antidepressants (especially selective serotonin reuptake inhibitors) are effective in preventing or reducing IFN-induced side-effects, but even these compounds are not 100% effective in preventing these symptoms. As such, alternative treatments must be considered. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to counteract a number of IFN-induced side effects, including cytokine activation, stress hormone release, and neurochemical alterations (reduced 5-HT [serotonin]). NSAIDs are widely recommended for various aspects of flu-like symptoms or sickness behaviors in humans, including those induced specifically by IFN. In addition, NSAIDs appear to be effective in treating premenstrual dysphoric disorder. These data indirectly specify a role for NSAIDs in syndromes with a prominent depression component. Drawing from an extensive pre-clinical and clinical research base, we hypothesize that pretreatment with NSAIDs will not only reduce the incidence of flu-like symptoms, but also prove effective for the prevention or reduction of IFN-induced depression.

AB - Interferon-alpha (IFN) is widely used for the treatment of viral illnesses and other chronic diseases, though its usefulness is hampered by a problematic side-effect profile. In particular, IFN-alpha induces neuropsychiatric and neurotoxic side effects, including depression, anxiety, insomnia, lethargy, confusion, and psychosis. Of particular interest, a number of patients develop full psychiatric syndromes, particularly depressive disorders. Recent evidence suggests that conventional antidepressants (especially selective serotonin reuptake inhibitors) are effective in preventing or reducing IFN-induced side-effects, but even these compounds are not 100% effective in preventing these symptoms. As such, alternative treatments must be considered. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to counteract a number of IFN-induced side effects, including cytokine activation, stress hormone release, and neurochemical alterations (reduced 5-HT [serotonin]). NSAIDs are widely recommended for various aspects of flu-like symptoms or sickness behaviors in humans, including those induced specifically by IFN. In addition, NSAIDs appear to be effective in treating premenstrual dysphoric disorder. These data indirectly specify a role for NSAIDs in syndromes with a prominent depression component. Drawing from an extensive pre-clinical and clinical research base, we hypothesize that pretreatment with NSAIDs will not only reduce the incidence of flu-like symptoms, but also prove effective for the prevention or reduction of IFN-induced depression.

UR - http://www.scopus.com/inward/record.url?scp=4644283429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644283429&partnerID=8YFLogxK

M3 - Article

C2 - 14608239

AN - SCOPUS:4644283429

VL - 37

SP - 29

EP - 50

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

SN - 0048-5764

IS - 3

ER -