TY - JOUR
T1 - Idiopathic systemic granulomatous disease and macrophage expression of PTHrP in a miniature pony
AU - Sellers, R. S.
AU - Toribio, R. E.
AU - Blomme, E. A.G.
PY - 2001
Y1 - 2001
N2 - Idiopathic systemic granulomatous disease, which has been reported in horses, cattle and human beings, is characterized by perivascular granulomatous and lymphoplasmacytic inflammation in many organ systems. Diagnosis is based on the exclusion of possible viral, fungal or bacterial causes. The disease was identified in a miniature pony with widespread lymphoplasmacytic and granulomatous inflammation, special staining techniques having revealed no evidence of any aetiological agent. Skin lesions, which were severe, consisted of hyperkeratosis and serocellular crust formation, with inflammatory infiltrates in a perivascular to diffuse pattern in both the superficial and deep dermis. Inflammatory infiltrates were also present in lymph nodes and around the blood vessels in most organs. Immunohistochemical, both CD3-positive T lymphocytes and BLA36-positive B lymphocytes were identified in the inflammatory infiltrates, and macrophages were immunolabelled for parthyroid hormone-related protein, a factor associated with hypercalcaemia in human beings with granulomatous diseases.
AB - Idiopathic systemic granulomatous disease, which has been reported in horses, cattle and human beings, is characterized by perivascular granulomatous and lymphoplasmacytic inflammation in many organ systems. Diagnosis is based on the exclusion of possible viral, fungal or bacterial causes. The disease was identified in a miniature pony with widespread lymphoplasmacytic and granulomatous inflammation, special staining techniques having revealed no evidence of any aetiological agent. Skin lesions, which were severe, consisted of hyperkeratosis and serocellular crust formation, with inflammatory infiltrates in a perivascular to diffuse pattern in both the superficial and deep dermis. Inflammatory infiltrates were also present in lymph nodes and around the blood vessels in most organs. Immunohistochemical, both CD3-positive T lymphocytes and BLA36-positive B lymphocytes were identified in the inflammatory infiltrates, and macrophages were immunolabelled for parthyroid hormone-related protein, a factor associated with hypercalcaemia in human beings with granulomatous diseases.
UR - http://www.scopus.com/inward/record.url?scp=0034751662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034751662&partnerID=8YFLogxK
U2 - 10.1053/jcpa.2001.0484
DO - 10.1053/jcpa.2001.0484
M3 - Article
C2 - 11578139
AN - SCOPUS:0034751662
SN - 0021-9975
VL - 125
SP - 214
EP - 218
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 2-3
ER -