Idiopathic systemic granulomatous disease and macrophage expression of PTHrP in a miniature pony

R. S. Sellers, R. E. Toribio, E. A G Blomme

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Idiopathic systemic granulomatous disease, which has been reported in horses, cattle and human beings, is characterized by perivascular granulomatous and lymphoplasmacytic inflammation in many organ systems. Diagnosis is based on the exclusion of possible viral, fungal or bacterial causes. The disease was identified in a miniature pony with widespread lymphoplasmacytic and granulomatous inflammation, special staining techniques having revealed no evidence of any aetiological agent. Skin lesions, which were severe, consisted of hyperkeratosis and serocellular crust formation, with inflammatory infiltrates in a perivascular to diffuse pattern in both the superficial and deep dermis. Inflammatory infiltrates were also present in lymph nodes and around the blood vessels in most organs. Immunohistochemical, both CD3-positive T lymphocytes and BLA36-positive B lymphocytes were identified in the inflammatory infiltrates, and macrophages were immunolabelled for parthyroid hormone-related protein, a factor associated with hypercalcaemia in human beings with granulomatous diseases.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalJournal of Comparative Pathology
Volume125
Issue number2-3
DOIs
StatePublished - 2001
Externally publishedYes

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Parathyroid Hormone-Related Protein
macrophages
inflammation
Macrophages
horses
hypercalcemia
hyperkeratosis
dermis
etiological agents
skin lesions
blood vessels
B-lymphocytes
Inflammation
lymph nodes
T-lymphocytes
hormones
Hypercalcemia
Dermis
Horses
Blood Vessels

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Idiopathic systemic granulomatous disease and macrophage expression of PTHrP in a miniature pony. / Sellers, R. S.; Toribio, R. E.; Blomme, E. A G.

In: Journal of Comparative Pathology, Vol. 125, No. 2-3, 2001, p. 214-218.

Research output: Contribution to journalArticle

Sellers, R. S. ; Toribio, R. E. ; Blomme, E. A G. / Idiopathic systemic granulomatous disease and macrophage expression of PTHrP in a miniature pony. In: Journal of Comparative Pathology. 2001 ; Vol. 125, No. 2-3. pp. 214-218.
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