Identifying protein-protein interactions in somatic hypermutation

Myron F. Goodman, Matthew D. Scharff

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent but change appears imminent. Here we comment on how, when, and why biochemistry is likely to emerge from the shadows and into the spotlight to elucidate how the somatic mutation of antibody variable (V) regions is generated.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalJournal of Experimental Medicine
Volume201
Issue number4
DOIs
StatePublished - Feb 21 2005

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Immunoglobulin Genes
Antibody Affinity
Medical Genetics
Biochemistry
Cultured Cells
Antigens
Mutation
Antibodies
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Identifying protein-protein interactions in somatic hypermutation. / Goodman, Myron F.; Scharff, Matthew D.

In: Journal of Experimental Medicine, Vol. 201, No. 4, 21.02.2005, p. 493-496.

Research output: Contribution to journalArticle

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