Identification of new epilepsy treatments: Issues in preclinical methodology

Aristea S. Galanopoulou, Paul S. Buckmaster, Kevin J. Staley, Solomon L. Moshé, Emilio Perucca, Jerome Engel, Wolfgang Löscher, Jeffrey L. Noebels, Asla Pitkänen, James Stables, H. Steve White, Terence J. O'Brien, Michele Simonato

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in a third of all affected individuals, and comorbidities still impose a major burden on quality of life. The introduction of multiple new therapies into clinical use over the past two decades has done little to change this. There is an urgent demand to address the unmet clinical needs for: (1) new symptomatic antiseizure treatments for drug-resistant seizures with improved efficacy/tolerability profiles, (2) disease-modifying treatments that prevent or ameliorate the process of epileptogenesis, and (3) treatments for the common comorbidities that contribute to disability in people with epilepsy. New therapies also need to address the special needs of certain subpopulations, that is, age- or gender-specific treatments. Preclinical development in these treatment areas is complex due to heterogeneity in presentation and etiology, and may need to be formulated with a specific seizure, epilepsy syndrome, or comorbidity in mind. The aim of this report is to provide a framework that will help define future guidelines that improve and standardize the design, reporting, and validation of data across preclinical antiepilepsy therapy development studies targeting drug-resistant seizures, epileptogenesis, and comorbidities.

Original languageEnglish (US)
Pages (from-to)571-582
Number of pages12
JournalEpilepsia
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Antiepileptogenesis
  • Antiseizure drug
  • Biomarkers
  • Comorbidities
  • Disease modification

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Galanopoulou, A. S., Buckmaster, P. S., Staley, K. J., Moshé, S. L., Perucca, E., Engel, J., Löscher, W., Noebels, J. L., Pitkänen, A., Stables, J., White, H. S., O'Brien, T. J., & Simonato, M. (2012). Identification of new epilepsy treatments: Issues in preclinical methodology. Epilepsia, 53(3), 571-582. https://doi.org/10.1111/j.1528-1167.2011.03391.x