Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus

E. Redolfi, Cristina Montagna, S. Mumm, M. Affer, L. Susani, R. Reinbold, F. Hol, P. Vezzoni, M. Cimino, I. Zucchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have identified and characterized a novel human gene (Nomenclature Committee of the Genome Database GDB-assigned symbol CXorf1) that maps to the long arm of the X chromosome in Xq27 between loci DXS369 and DXS181, approximately 2.5 Mb centromeric to the FMR1 gene. The CXorf1 gene is conserved in primates, cow, and horse but not in mouse and rat. Northern blot analysis revealed two transcripts, present in the brain and in the G361 melanoma cell line. In situ hybridization experiments performed on sections of human hippocampus showed a clear, uneven localization of the CXorf1 mRNA in specific subfields of this brain area. In particular, CXorf1 was localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammon's horn. CXorf1 is one of the first genes from this region to be characterized in detail and, on the basis of its chromosomal location and expression pattern, may have an important function in the brain.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalDNA and Cell Biology
Volume17
Issue number12
StatePublished - Dec 1998
Externally publishedYes

Fingerprint

Hippocampus
Genes
Brain
Dentate Gyrus
X Chromosome
Terminology
Northern Blotting
Primates
Horses
In Situ Hybridization
Melanoma
Genome
Databases
Cell Line
Messenger RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Redolfi, E., Montagna, C., Mumm, S., Affer, M., Susani, L., Reinbold, R., ... Zucchi, I. (1998). Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus. DNA and Cell Biology, 17(12), 1009-1016.

Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus. / Redolfi, E.; Montagna, Cristina; Mumm, S.; Affer, M.; Susani, L.; Reinbold, R.; Hol, F.; Vezzoni, P.; Cimino, M.; Zucchi, I.

In: DNA and Cell Biology, Vol. 17, No. 12, 12.1998, p. 1009-1016.

Research output: Contribution to journalArticle

Redolfi, E, Montagna, C, Mumm, S, Affer, M, Susani, L, Reinbold, R, Hol, F, Vezzoni, P, Cimino, M & Zucchi, I 1998, 'Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus', DNA and Cell Biology, vol. 17, no. 12, pp. 1009-1016.
Redolfi E, Montagna C, Mumm S, Affer M, Susani L, Reinbold R et al. Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus. DNA and Cell Biology. 1998 Dec;17(12):1009-1016.
Redolfi, E. ; Montagna, Cristina ; Mumm, S. ; Affer, M. ; Susani, L. ; Reinbold, R. ; Hol, F. ; Vezzoni, P. ; Cimino, M. ; Zucchi, I. / Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus. In: DNA and Cell Biology. 1998 ; Vol. 17, No. 12. pp. 1009-1016.
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