Identification of cells infiltrating the minor salivary glands in patients with Sjogren's syndrome

T. M. Chused, J. A. Hardin, M. M. Frank, I. Green

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Patients with Sjogren's syndrome (SS) have mononuclear cell infiltration, tissue destruction and eventual fibrosis of the salivary and lacrimal glands. The type of mononuclear cell infiltrating the minor salivary glands of the lip in three patients with SS was determined. Sheep erythrocytes coated with 19S antibody and activated third component of complement were found to adhere to human bone marrow derived (B) cells and monocytes in tissue sections. Erythrocytes coated with 7S antibody adhered only to monocytes. The localization of these reagents in tissue sections was used to demonstrate that the major portion of mononuclear cells infiltrating SS salivary tissue are B cells and that they are arranged in a particular way in the infiltrate.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalJournal of Immunology
Volume112
Issue number2
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Chused, T. M., Hardin, J. A., Frank, M. M., & Green, I. (1974). Identification of cells infiltrating the minor salivary glands in patients with Sjogren's syndrome. Journal of Immunology, 112(2), 641-648.