Hypothalamic sensing of fatty acids

Tony K.T. Lam, Gary J. Schwartz, Luciano Rossetti

Research output: Contribution to journalReview article

330 Scopus citations


Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalNature Neuroscience
Issue number5
StatePublished - May 1 2005


ASJC Scopus subject areas

  • Neuroscience(all)

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