Hypothalamic sensing of fatty acids

Tony K.T. Lam; Gary J. Schwartz; Luciano Rossetti

doi:10.1038/nn1456

Hypothalamic sensing of fatty acids

Tony K.T. Lam, Gary J. Schwartz, Luciano Rossetti

Medicine

Research output: Contribution to journal › Review article › peer-review

383 Scopus citations

Abstract

Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

Original language	English (US)
Pages (from-to)	579-584
Number of pages	6
Journal	Nature Neuroscience
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/nn1456
State	Published - May 2005

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nn1456

Cite this

@article{5c5fbae820384193af96b2aecd2c6fac,

title = "Hypothalamic sensing of fatty acids",

abstract = "Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.",

author = "Lam, {Tony K.T.} and Schwartz, {Gary J.} and Luciano Rossetti",

note = "Funding Information: This work was supported by the Skirball Institute, grants from the National Institutes of Health (to L.R.: DK45024, DK48321 and AG21654; to G.J.S.: DK47208) and grants from the Albert Einstein College of Medicine Diabetes Research & Training Center (DK20541). T.K.T. Lam is supported by a training grant from the National Institute of Aging (T32-AG023475).",

year = "2005",

month = may,

doi = "10.1038/nn1456",

language = "English (US)",

volume = "8",

pages = "579--584",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Hypothalamic sensing of fatty acids

AU - Lam, Tony K.T.

AU - Schwartz, Gary J.

AU - Rossetti, Luciano

N1 - Funding Information: This work was supported by the Skirball Institute, grants from the National Institutes of Health (to L.R.: DK45024, DK48321 and AG21654; to G.J.S.: DK47208) and grants from the Albert Einstein College of Medicine Diabetes Research & Training Center (DK20541). T.K.T. Lam is supported by a training grant from the National Institute of Aging (T32-AG023475).

PY - 2005/5

Y1 - 2005/5

N2 - Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

AB - Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

UR - http://www.scopus.com/inward/record.url?scp=17844379953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17844379953&partnerID=8YFLogxK

U2 - 10.1038/nn1456

DO - 10.1038/nn1456

M3 - Review article

C2 - 15856066

AN - SCOPUS:17844379953

SN - 1097-6256

VL - 8

SP - 579

EP - 584

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 5

ER -

Hypothalamic sensing of fatty acids

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this